GSK · 11 hours ago
Principal Scientist – Translational Science – Neurodegeneration
USA - Pennsylvania - Upper Providence
Full-time
Onsite
Senior Level, Lead/Staff
4+ years expGSK is a global biopharma company focused on uniting science, technology, and talent to advance health. The Principal Scientist will play a critical role in bridging preclinical target validation and early clinical proof of concept studies by designing and performing translational assays in human-derived samples.
BiotechnologyHealth CarePharmaceutical
Responsibilities
Design, execute, and analyze laboratory experiments to advance scientific understanding and support drug discovery
Apply hands-on expertise in several of the following capabilities: ELISA/MSD/Quanterix, Western/JESS, flow cytometry, gene expression analysis, iPSC cell culture, and emerging technologies
Maintain accurate and detailed laboratory records in alignment with data integrity expectations and ensure compliance with all relevant protocols and safety guidelines
Effectively trouble-shoot assays and, when necessary, develop alternative approaches
Work closely with preclinical statistics and other relevant teams to ensure robust study design of experiments
Present findings to internal teams, stakeholders, and governance in a balanced, clear, and precise manner
Work closely with key partners to design, optimize, and execute studies to strengthen target-disease hypotheses and provide evidence for GSK translational pillars by using human ex vivo samples
Provide technical and disease input into the translational strategy for one or more projects and influence project direction through interpretation and integration of relevant project and other data
Utilize a growing internal and external network to build translational expertise in technology and disease areas; act as a go-to expert on specific technologies and/or disease mechanisms in neurodegeneration
Identify and progress collaborations with external partners, including academic institutions and contract research organizations, to leverage expertise and resources to support translational studies
Stay up to date with the latest scientific literature and emerging technologies relevant to translational research
Ensure compliance with all applicable laws, regulations, and ethical standards in the conduct of translational research
Foster a culture of innovation, collaboration, and continuous learning within the translational research team and across the organization
Qualification
Required
PhD in a relevant scientific discipline (e.g., Neuroscience, Immunology, Molecular Biology, Genetics, or related field)
4+ years' experience in translational science, biomarker development, and drug discovery
Experience in neurodegeneration disease area
Hands-on experience in several of the following technical capabilities: bioassay development and analysis (ELISA/MSD/Quanterix), flow cytometry, DNA and RNA sequencing technologies, iPSC cell culture, and emerging technologies
Experience in human systems using cell and molecular biology, bioassays, and analytic methods
Experience in neurodegenerative disease mechanisms and pathways and the ability to apply this knowledge to translational research and biomarker development
Experience with scientific innovation as evidenced by effective support of drug discovery projects, peer-reviewed publications, conferences, internal reports, technical evidence documents or patents
Preferred
Excellent problem-solving skills and ability to critically analyze scientific data
Familiarity with bioinformatics tools for the interpretation of large-scale datasets
Strong written and verbal communication skills, with the ability to effectively present scientific findings to multidisciplinary internal and external stakeholders in a balanced, clear, and precise manner
Proven ability to balance priorities across multiple objectives, meeting timelines while maintaining attention to detail and high-performance standards
Able to independently define strategic approach to tackle specific project or department goals
Ability to work independently as well as collaboratively in a team-oriented environment
Resourcefulness to access cutting-edge technologies, tools, reagents, biosamples, biomarker expertise, and research capabilities
Experience in the design and execution of biomarker-driven clinical trials and the development of companion diagnostics
Knowledge of regulatory guidelines and compliance requirements related to translational research and clinical development
Company
GSK
We are uniting science, technology and talent to get ahead of disease together. Our community guidelines: https://gsk.to/socialmedia
10001+ employees
H1B Sponsorship
GSK has a track record of offering H1B sponsorships. Please note that this does not
guarantee sponsorship for this specific role. Below presents additional info for your
reference. (Data Powered by US Department of Labor)
Distribution of Different Job Fields Receiving Sponsorship
Represents job field similar to this job
Trends of Total Sponsorships
2025 (45)
2024 (56)
2023 (54)
2022 (53)
2021 (54)
2020 (72)
Funding
Current Stage
Public CompanyTotal Funding
$25.51MKey Investors
CARB-X
2021-03-02Grant· $18M
2020-09-23Grant· $7.51M
1978-01-13IPO
Leadership Team
Julie Brown
CFO
Mike Elmore
SVP & Chief Information Security Officer, GSK
Recent News
2026-01-16
2026-01-13
South China Morning Post
2026-01-08
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