Senior Scientist or Engineer in Single-cell sequencing jobs in United States
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Shennon Biotechnologies · 13 hours ago

Senior Scientist or Engineer in Single-cell sequencing

positionSan Francisco, CA
timeFull-time
remoteOnsite
seniorityMid, Senior Level
money$120K/yr - $150K/yr

Shennon Biotechnologies is a well-funded biotech startup that has developed a proprietary ultrafast screening platform for immunotherapy. They are seeking a Senior Scientist or Engineer with experience in developing DNA/RNA sequencing chemistries and methods to join their interdisciplinary team.

BiotechnologyLife ScienceMedical

Responsibilities

Design, optimize, and execute single-cell sequencing assays, including mRNA capture, RT-PCR, PCR, and NGS library preparation
Formulate and optimize reagent mixtures to enhance mRNA capture efficiency, cell viability, and signal-to-noise within droplets
Develop and refine in-droplet biochemical reactions, including cDNA synthesis, amplification, and cell activation assays
Design bead chemistry and barcoding strategies for different sequencing applications
Evaluate and mitigate cross-contamination through chemistry, workflow, and process optimization, including microfluidic chip optimization and assay design
Design assays and metrics to characterize sequencing quality, including cross-contamination rates, read depth and sequencing cost efficiency, and cell-type clustering and phenotype/genotype resolution
Innovate new sequencing chemistries to advance high-throughput single cell sequencing technologies (custom library design, custom chemistry/reagents)

Qualification

Single-cell sequencing chemistryAssay developmentMicrofluidic devicesNGS library preparationMolecular barcoding strategiesData analysisCommunication skillsAdaptability

Required

PhD in biochemistry, molecular biology, bioengineering or related field with significant experience in developing sequencing chemistries
Deep expertise in custom single-cell sequencing chemistry and assay development
Familiarity with operating microfluidic devices and with droplet-based microfluidics
Hands-on experience with droplet-based single cell sequencing workflows and NGS library preparation
Experience working with and designing barcoded beads and molecular barcoding strategies, including exposure to bead functionalization or surface chemistry optimization
Comfortable with working in fast-moving, early-stage and platform-development environments

Preferred

Experience with single-cell sequencing data analysis is a plus

Benefits

4% Salary 401K match
Daily lunches
Commuter Benefits
Unlimited snacks and drinks
Medical, Dental, Vision; 100% Premium Covered
Disability Insurance
Life Insurance
Workplace Insurance

Company

Shennon Biotechnologies

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ShennonBio analyzes and manipulates a massive number of cells on the single cell level to develop better treatments for human diseases.
dateFounded in 2021
location
San Francisco, California, USA
people-size11-50 employees
web-link
https://www.shennonbio.com/

Funding

Current Stage
Early Stage
Total Funding
$13M
Key Investors
DCVC
2023-03-13Seed· $13M

Leadership Team

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Li Sun, PhD
Founder/CEO
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Recent News

DCVC
DCVC leads $13 million seed funding for ShennonBio — revolutionizing immunotherapy through immune cell profiling at unprecedented accuracy, speed
2025-04-18
Google Patent
Microfluidic devices for high throughput screening of cell-cell interactions
2025-02-10
VatorNews
Digital health news, funding round up in the prior week; March 20, 2023
2023-03-21
Company data provided by crunchbase