Kernal Biologics · 13 hours ago
Senior Associate Scientist, LNP Formulation
Cambridge, MA
Full-time
Onsite
Mid, Senior Level
3+ years expKernal Bio is a venture-backed therapeutics company engineering cells inside the body using AI-designed, selective mRNA and targeted LNP technology. They are seeking a highly motivated Senior Associate Scientist to support the development of its targeted lipid nanoparticle (tLNP) platform, emphasizing hands-on laboratory work and collaboration with cross-functional partners. The role involves synthesizing and characterizing LNPs, optimizing formulations, and supporting technology transfer activities.
BiotechnologyPharmaceuticalTherapeutics
Responsibilities
Synthesize and characterize LNP's for preclinical studies
Analyze LNP critical quality attributes using techniques such as Dynamic Light Scattering (DLS), RiboGreen assays, HPLC, and related analytical methods
Support the development of antibody-LNP conjugation workflows and processes
Perform formulation screening studies, including buffer and excipient optimization to improve LNP stability and performance
Support the execution of flow cytometry-based assays for LNP screening and optimization
Assist with the development, optimization, and troubleshooting of LNP/mRNA manufacturing processes at bench and pilot scales
Assist in the development, qualification, and execution of analytical and functional assays to assess key LNP attributes
Analyze experimental data, maintain detailed records in ELNs, and prepare summaries and presentations for internal team discussions
Support technology transfer activities to internal CMC teams and external partners, as needed
Maintain laboratory organization, supplies, and reagent inventories for the LNP Formulation team
Contribute to technical discussions and documentation related to platform development and intellectual property
Qualification
Required
BS/MS in Chemical Engineering, Biomedical Engineering, Bioengineering, Pharmaceutics, Chemistry or related field along with 3-5 years of industry experience working with lipid nanoparticles, polymeric nanoparticles, or similar
Hands-on experience manufacturing LNPs using Microfluidics, T-mixer, or other inline mixers
Experience with tangential flow filtration (TFF) and sterile filtration
Familiarity with related LNP/mRNA analytical techniques (e.g. plate-based fluorescence assays, HPLC, LC/MS)
Experience supporting in vivo LNP studies; direct execution experience is a plus
Familiarity with ELN and GraphPad Prism
Attention to detail, ability to multi-task, and complete deliverables within timelines
Strong written and verbal communication skills
Preferred
Exposure to tech transfer activities or GMP manufacturing environments
Benefits
Competitive 401(k)
Highly competitive healthcare coverage (PPO/HMO)
Free parking, a monthly subway pass, or a subsidized commuter rail pass
Free Bluebike Membership
Gym Membership Support
Flexible Spending Account
Paid parental leave, family caregiver leave, and medical leave
Paid life insurance coverage
On-site cafeteria
Competitive vacation and sick days per year
Company
Kernal Biologics
Kernalbio creates mRNA therapies that instruct specific cells on how to make their own medicine.
11-50 employees
H1B Sponsorship
Kernal Biologics has a track record of offering H1B sponsorships. Please note that this does not
guarantee sponsorship for this specific role. Below presents additional info for your
reference. (Data Powered by US Department of Labor)
Distribution of Different Job Fields Receiving Sponsorship
Represents job field similar to this job
Trends of Total Sponsorships
2025 (1)
2024 (2)
2021 (1)
Funding
Current Stage
Early StageTotal Funding
$73MKey Investors
Advanced Research Projects Agency for HealthHummingbird Ventures
2025-10-07Grant· $48M
2022-07-07Series A· $25M
2020-10-21Seed
Leadership Team
B
Burak Yilmaz
Founder & President
Recent News
Google Patent
2025-02-08
Company data provided by crunchbase