Flagship Pioneering · 18 hours ago
Senior Scientist, Protein Assay Development and Screening
Cambridge, MA USA
Full-time
Onsite
Mid, Senior Level
$126K/yr - $182K/yr
5+ years expFlagship Pioneering is an early-stage biotechnology company transforming the way biomolecules are synthesized. They are seeking a creative and motivated Senior Scientist to lead high-throughput protein expression and assay development, focusing on building scalable workflows for protein generation and functional screening.
FinanceFinancial ServicesVenture Capital
Responsibilities
Develop scalable high-throughput expression systems in coli and cell-free formats for protein production across diverse constructs and libraries
Design and implement multiplexed protein screening assays using plate-based readouts (e.g., fluorescence, luminescence, absorbance), mobility-based platforms (e.g., LabChip, TapeStation), and other automated methods
Generate and analyze large experimental datasets to extract actionable insights, inform platform improvements, and feed downstream ML models
Collaborate closely with cross-functional partners, including machine learning scientists, chemists, and biochemists, to ensure cohesive integration across the platform
Contribute to team building, lab infrastructure, and the overall strategic direction of the team
Document experimental results rigorously, communicate clearly, and present findings effectively to internal and external stakeholders
Qualification
Required
D. in Biochemistry, Protein Engineering, Synthetic Biology, Molecular Biology, or related discipline, with 5+ years of relevant industry experience
Hands-on expertise in high-throughput protein expression (bacterial and/or cell-free systems) and purification
Strong track record of designing and executing quantitative protein assays at scale
Experience handling, analyzing, and interpreting large biological datasets
Demonstrated ability to work collaboratively in a dynamic, fast-paced environment
Clear and concise communicator with excellent organizational and problem-solving skills
Proficiency in protein and nucleic acid characterization techniques (LabChip, platereader, gel electrophoresis, TapeStation/Fragment Analyzer, sequencing technologies, Mass Spectrometry)
Benefits
Healthcare coverage
Annual incentive program
Retirement benefits
Broad range of other benefits
Company
Flagship Pioneering
Flagship Pioneering is a venture capital firm that invests in life sciences and healthcare companies.
501-1000 employees
H1B Sponsorship
Flagship Pioneering has a track record of offering H1B sponsorships. Please note that this does not
guarantee sponsorship for this specific role. Below presents additional info for your
reference. (Data Powered by US Department of Labor)
Distribution of Different Job Fields Receiving Sponsorship
Represents job field similar to this job
Trends of Total Sponsorships
2025 (8)
2024 (4)
2023 (4)
2022 (4)
2021 (1)
Funding
Current Stage
Late StageLeadership Team
Noubar Afeyan
Founder and CEO
Chuck Carelli
Chief Financial Officer
Recent News
2026-01-16
2026-01-16
Company data provided by crunchbase