Eli Lilly and Company · 8 hours ago
Associate Scientist
Boston, MA
Full-time
Onsite
Entry Level
$71K/yr - $187K/yr
2+ years expEli Lilly and Company is a global healthcare leader headquartered in Indianapolis, Indiana, focused on discovering and advancing life-changing medicines. The Associate Scientist will join the Gene Therapy team, responsible for developing and optimizing genetic therapeutics through laboratory-based experimentation and collaboration with internal and external partners.
BiotechnologyHealth CareMedicalPharmaceutical
No H1B
Responsibilities
Develop genetically controlled biological gene expression switches with external and internal partners to enhance the safety and tunability of gene therapy approaches
Screen and characterize small molecule libraries for optimal switch performance, including potency and selectivity
Optimize genetic switch architectures by engineering promoters, response elements, and transactivator systems to enhance dynamic range and minimize basal expression
Establish primary cell and cell line models to test switch functionality, dose-response curves, and temporal kinetics under physiologically relevant conditions
Translate optimized switches into animal models, assessing biodistribution, duration of expression, and therapeutic efficacy in disease-relevant tissues
Determine optimal dosing regimens, evaluate onset/offset kinetics, and establish correlation between small molecule exposure and gene expression levels
Troubleshoot translational challenges - Address issues such as immune responses, tissue-specific expression variations, and differences between in vitro and in vivo switch performance
Work with partners to understand PK/PD relationships and optimize delivery strategies for both the genetic switch components and small molecule regulators
Maintain detailed documentation of scientific work in an electronic notebook
Qualification
Required
B.S. and/or M.S. in biology or a closely related field
2+ years of relevant laboratory experience
Qualified applicants must be authorized to work in the United States on a full time basis. Lilly will not provide support for or sponsor work authorization and or visas for this role
Preferred
Significant aseptic cell culture experience, including gene therapy (e.g. AAV or LNP) experiments
Experience isolating nucleic acids and proteins from cells and tissues
Experience in in vitro design and evaluation of biological kill switches
Experience planning and implementing experiments independently
Experience in laboratory techniques including DNA/RNA purification and analysis (qPCR, ddPCR, RT-qPCR, NGS), protein analysis (Simple Western Jess, ELISA, MSD, Octet) and flow cytometry
Familiarity with primer design, sequencing preparation, and analysis
Prior training in gene therapy, HIV, and Human HSC derived cell culture is a plus
Experience using automation in workflows is a plus (i.e., liquid handling)
Excellent problem-solving skills and ability to troubleshoot complex issues
Strong organization, communication, and collaboration skills
Benefits
Company-sponsored 401(k)
Pension
Vacation benefits
Eligibility for medical, dental, vision and prescription drug benefits
Flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts)
Life insurance and death benefits
Certain time off and leave of absence benefits
Well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities)
Company
Eli Lilly and Company
We're a medicine company turning science into healing to make life better for people around the world.
10001+ employees
Funding
Current Stage
Public CompanyTotal Funding
$6.5M2024-02-12Post Ipo Debt· $6.5M
1978-01-13IPO
Leadership Team
David Ricks
Chair, CEO
Lucas Montarce
Executive Vice President and Chief Financial Officer
Recent News
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