Eli Lilly and Company · 3 hours ago
Senior Director Technical Operations - Radioligand Therapies
Indianapolis, IN
Full-time
Onsite
Director/Executive
$178K/yr - $262K/yr
10+ years expEli Lilly and Company is a global healthcare leader headquartered in Indianapolis, Indiana, dedicated to discovering life-changing medicines. The Senior Director of Technical Operations will provide scientific and technical leadership across Radioligand Therapy programs, ensuring robust execution and alignment across teams while managing complex development and manufacturing challenges.
BiotechnologyHealth CareMedicalPharmaceutical
Responsibilities
Serve as the primary technical authority for RLT manufacturing and analytical topics, applying deep scientific rigor to guide teams through complexity
Demonstrate calm, decisive leadership when challenges arise, using evidence‑based reasoning to drive resolution and maintain supply continuity
Influence strategy and decision‑making by providing clear scientific rationale, shaping development approaches, and ensuring teams are aligned on technical priorities
Lead all aspects of technology transfer for drug substance and drug product, ensuring analytical methods, process design, and validation strategies are scientifically robust and phase‑appropriate
Drive seamless scale‑up and readiness for late‑stage clinical manufacturing
Guide teams through technical ambiguity—diagnosing root causes, developing solutions, and aligning internal and external partners on clear paths forward
Identify, establish, and maintain strong technical partnerships with CDMOs for manufacturing and analytical services
Serve as the primary scientific and technical point of contact to resolve deviations, supply risks, and complex technical issues at CDMOs
Define and monitor metrics to ensure external manufacturing reliability and proactive risk mitigation for global RLT supply
Partner closely with CMC development and translational radiochemistry teams to proactively identify and resolve scientific and operational challenges
Review and approve GMP documentation (OOS, deviations, change controls) with strong technical judgment
Ensure adherence to regulatory requirements and internal quality standard
Develop and implement science‑driven strategies to optimize manufacturing processes and analytical methods
Drive continuous improvement initiatives for efficiency and compliance
Create and manage technical operations budgets, including OPEX and CAPEX
Oversee global technical operations including new manufacturing site qualification, technical troubleshooting, manufacturing procedure alignment, and management of Lilly‑owned equipment at contract sites
Partner with discovery, development, clinical, regulatory, and supply chain teams to shape program strategy, integrate scientific insights, and drive timely decision‑making
Influence teams by translating complex technical concepts into clear, actionable recommendations that support development decisions
Support regulatory submissions with high‑quality technical content and scientifically sound responses
Anticipate, identify, and mitigate scientific, technical, operational, and supply chain risks across the RLT manufacturing network. Lead stakeholders through complexity by aligning on mitigation plans and enabling data‑driven decisions under uncertainty
Develop and mentor talent, fostering a culture of scientific excellence, accountability, and continuous improvement
Provide steady, influential leadership that empowers teams and sustains performance through change and ambiguity
Qualification
Required
Bachelor's degree in Chemistry, Pharmaceutical Sciences, Chemical Engineering, or related field
10+ years of experience in technical operations within the pharmaceutical or radiopharmaceutical industry
Proven expertise in GMP, CMC regulatory requirements, and CDMO tech transfer
Strong scientific leadership and vendor‑management skills
Excellent communication and problem‑solving abilities; creative thinking and ability to cultivate innovation
Familiarity with global regulatory frameworks (FDA, EMA, ICH)
Legally authorized to be employed in the United States or Canada
Willingness and ability to travel globally up to 20%
Preferred
Advanced degree in Chemistry, Pharmaceutical Sciences, Chemical Engineering, or related field
Experience with radioligand therapy or complex drug modalities
Ability to manage multiple projects in a fast‑paced environment
Demonstrated ability to lead through ambiguity and drive engagement among teams
Ability to adapt to change and be a nimble learner
Benefits
Eligibility to participate in a pension plan
Vacation benefits
Eligibility for healthcare benefits
Flexible benefits (if applicable)
Life insurance and death benefits
Certain time off and leave of absence benefits
Well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities)
Company
Eli Lilly and Company
We're a medicine company turning science into healing to make life better for people around the world.
10001+ employees
H1B Sponsorship
Eli Lilly and Company has a track record of offering H1B sponsorships. Please note that this does not
guarantee sponsorship for this specific role. Below presents additional info for your
reference. (Data Powered by US Department of Labor)
Distribution of Different Job Fields Receiving Sponsorship
Represents job field similar to this job
Trends of Total Sponsorships
2025 (514)
2024 (236)
2023 (167)
2022 (133)
2021 (57)
2020 (52)
Funding
Current Stage
Public CompanyTotal Funding
$6.5M2024-02-12Post Ipo Debt· $6.5M
1978-01-13IPO
Leadership Team
David Ricks
Chair, CEO
Lucas Montarce
Executive Vice President and Chief Financial Officer
Recent News
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