Tango Therapeutics · 12 hours ago
Director, IT Governance, Risk, and Compliance (GRC)
Boston, MA
Full-time
Onsite
Director/Executive
$166K/yr - $248K/yr
10+ years expTango Therapeutics is a biotechnology company dedicated to discovering novel drug targets and delivering the next generation of precision medicine for the treatment of cancer. The Director, IT GRC will be responsible for establishing and maintaining the IT governance, risk management, and compliance framework, ensuring that IT systems and processes meet regulatory and business requirements.
BiotechnologyHealth CareMedicalTherapeutics
Responsibilities
Own the development, maintenance, and enforcement of IT policies, SOPs, work instructions, and department- and company-wide processes
Establish and maintain a scalable IT governance framework aligned with company growth and regulatory expectations
Ensure policies and procedures align with industry best practices and regulatory standards, including NIST, GxP, and SOX
Partner with IT and business stakeholders to operationalize governance requirements across the organization
Lead IT risk identification, assessment, and mitigation activities across systems and processes
Support enterprise risk management initiatives as they relate to IT, cybersecurity, and regulated systems
Ensure IT risks are documented, tracked, and addressed in a risk-based and pragmatic manner
Align IT risk management practices with recognized frameworks such as NIST
Serve as the primary IT owner for external regulatory compliance initiatives, including SOX, GxP, EU Annex 11, and other applicable U.S., EU, and UK regulations
Ensure IT controls are designed, implemented, and operating effectively to support audit and inspection readiness
Act as a key IT liaison during internal audits, external audits, and regulatory inspections
Manage IT-related audit responses, findings, and corrective and preventive actions (CAPAs)
Oversee IT system validation activities for new and existing systems in regulated environments
Ensure validation documentation, testing, approvals, and traceability are completed in a compliant and inspection-ready manner
Own or support IT change control processes, ensuring changes are properly assessed, approved, tested, and documented
Partner closely with Quality and system owners to ensure validation activities meet regulatory and company standards
Provide governance and oversight for IT initiatives, ensuring delivery aligns with compliance, risk, and business priorities
Integrate compliance, validation, and risk considerations into project planning and execution
Coordinate with internal teams and external vendors to drive accountability and delivery
Track project risks, dependencies, and milestones, escalating issues as appropriate
Support IT vendor qualification and oversight activities in partnership with Quality
Participate in vendor assessments and audits as needed, including occasional travel with Quality for inspections
Ensure vendor-managed systems and services meet Tango’s governance and compliance expectations
Qualification
Required
Bachelor's degree in Information Systems, Computer Science, or a related field
10+ years of experience in IT governance, compliance, validation, risk, or quality roles within a regulated life sciences environment
Demonstrated experience supporting GxP, SOX, and Annex 11 compliance
Strong understanding of IT system validation, change control, and documentation requirements
Hands-on experience creating and maintaining IT policies, SOPs, and governance frameworks
Experience supporting internal and external audits and regulatory inspections
Proven ability to operate as a senior individual contributor with ownership and accountability
Strong project management skills with the ability to manage multiple initiatives concurrently
Excellent written and verbal communication skills, with the ability to translate regulatory requirements into practical implementation
Detail-oriented, risk-aware, and pragmatic in approach
Preferred
Experience in a clinical-stage or commercializing biotech or pharmaceutical company
Familiarity with FDA regulations (e.g., 21 CFR Part 11) and global regulatory expectations
Experience partnering closely with Quality, Clinical Operations, Finance, and Legal teams
Exposure to enterprise systems such as QMS/eQMS, RIMS, CTMS, ERP, or financial systems
Formal project management training or certification (e.g., PMP) a plus
Company
Tango Therapeutics
Tango Therapeutics is a biotechnology company that is developing next generation cancer therapies.
51-200 employees
H1B Sponsorship
Tango Therapeutics has a track record of offering H1B sponsorships. Please note that this does not
guarantee sponsorship for this specific role. Below presents additional info for your
reference. (Data Powered by US Department of Labor)
Distribution of Different Job Fields Receiving Sponsorship
Represents job field similar to this job
Trends of Total Sponsorships
2025 (1)
2024 (2)
2023 (1)
2022 (2)
2021 (1)
2020 (3)
Funding
Current Stage
Public CompanyTotal Funding
$548MKey Investors
Nextech InvestBoxer CapitalCasdin Capital
2025-10-23Post Ipo Equity· $197M
2021-08-11Post Ipo Equity· $186M
2021-08-11IPO
Leadership Team
Barbara Weber
President and CEO
Jannik N. Andersen
Chief Scientific Officer
Recent News
2026-01-11
2026-01-09
Company data provided by crunchbase