MD Anderson Cancer Center · 15 hours ago
Data Scientist (Bioinformatics Developer) - Next Generation Sequencing (NGS)
Houston, TX
Full-time
Onsite
Mid, Senior Level
$106K/yr - $160K/yr
3+ years expMD Anderson Cancer Center is at the forefront of precision oncology, leveraging advanced genomic technologies for patient care. As a Data Scientist (Bioinformatics Developer), you will develop and maintain bioinformatics pipelines and clinical informatics applications that support molecular diagnostic testing and genomic reporting, collaborating closely with various stakeholders to translate complex biological questions into computational solutions.
Health CareHealth DiagnosticsHospitalMedical
Responsibilities
Development, Optimization, Deployment and Maintenance of Clinical Informatics Applications and Bioinformatics Pipelines
Support functional development of the OncoSeek genomics annotation and reporting engine which has been used to generate genomic next-generation sequencing panel reports at MD Anderson since 2012
Support, develop and maintain MDLConductor laboratory informatics system(LIS) and applications for MDL. Specific efforts include but are not limited to, integrate MDL LIS with hospital informatics system, develop automated rack label and vial label printing with real-time Micronics tube mapping for stock tube management for all derivative sample types (e.g. DNA, RNA, cDNA), coordinate interfacing with existing robotic sample storage (ASR), quantitation devices (Synergy), and robotic fluid handlers for plate setups & core laboratory workflows
Design and implement algorithms and statistical methods for the interpretation of genomic data, including identification of genetic variants, differential expression analysis, and pathway analysis. This requires a deep understanding of both bioinformatics theory and practical applications to derive meaningful insights from complex genomic datasets
Collaborate with molecular diagnostics professionals to understand project requirements, propose solutions, and provide technical support for data analysis and interpretation. This involves actively engaging with project teams to translate biological questions into computational workflows and troubleshooting issues that arise during data analysis
Develop Bioinformatics pipelines for various next generation sequencing (NGS) applications such as whole transcriptome sequencing(WTS), whole genome sequencing (WGS), exome sequencing (WES), targeted sequencing, single-cell sequencing, liquid biopsy analysis, and minimal residual disease (MRD) detection. This includes adapting existing pipelines and developing new methodologies to address the specific requirements and challenges associated with each application. This also includes processing and analyzing NGS and other genomic data, including tasks such as quality control, alignment, variant calling, and annotation
Integrate existing bioinformatics tools and databases into custom workflows to address specific clinical application needs and improve analysis efficiency. This includes evaluating the suitability of available tools and databases for particular analyses and developing scripts or wrappers to automate data processing tasks and facilitate reproducibility. This involves staying up-to-date with the latest tools and methods in the field and integrating them into existing pipelines to ensure accurate and efficient analysis, and actively monitoring scientific literature, attending conferences, and participating in online forums and community discussions to identify emerging trends and technologies relevant to genomics research
Maintain documentation and version control for developed software and pipelines, ensuring reproducibility and transparency of analyses. This includes writing comprehensive documentation for code and pipelines, managing code repositories using version control systems such as Git, and adhering to best practices for software development and data management
Participate in team meetings, seminars, and training sessions to share knowledge and best practices in bioinformatics analysis. This includes presenting updates on ongoing projects, leading discussions on relevant topics in bioinformatics, and providing training to team members on new tools and methods
Provide support and training to other team members, including laboratory staff, precision oncology scientists, bioinformaticians, pathologists and clinical oncologists, on the use of bioinformatics tools and data analysis techniques. This involves offering guidance on experimental design, data preprocessing, and interpretation of results, as well as troubleshooting issues and answering technical questions to facilitate productive collaborations across disciplines
Qualification
Required
Bachelor's Degree in Biomedical Engineering, Electrical Engineering, Computer Engineering, Physics, Applied Mathematics, Science, Engineering, Computer Science, Statistics, Computational Biology, or related field
3 years of scientific software or industry development/analysis experience OR
1 year of required experience with a Master's Degree OR
With a PhD, no experience required
Preferred
Master's Degree in Science, Engineering, or related field
PhD in Science, Engineering, or related field
Benefits
Paid medical benefits
Generous paid time off
Retirement plans
Tuition benefits
Educational opportunities
Individual and team recognition
Medical
Dental
Company
MD Anderson Cancer Center
MD Anderson Cancer Center is a cancer treatment and research institution which gives treatment, and research of all types of cancer.
10001+ employees
H1B Sponsorship
MD Anderson Cancer Center has a track record of offering H1B sponsorships. Please note that this does not
guarantee sponsorship for this specific role. Below presents additional info for your
reference. (Data Powered by US Department of Labor)
Distribution of Different Job Fields Receiving Sponsorship
Represents job field similar to this job
Trends of Total Sponsorships
2021 (1)
Funding
Current Stage
Late StageTotal Funding
$16.2MKey Investors
Break Through CancerGastro-Intestinal Research Foundation
2023-05-16Grant· $2.7M
2023-01-24Grant· $3.5M
2022-04-19Grant· $10M
Leadership Team
D
David Tweardy
Professor
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