Genentech · 17 hours ago
ITOT Systems Release Manager
Hillsboro, OR
Full-time
Onsite
Mid, Senior Level
$104K/yr - $230K/yr
5+ years expGenentech is a leading biotechnology company focused on innovative medicine. They are seeking an ITOT Systems Release Manager who will be responsible for managing system releases and downtimes across the IT/OT ecosystem, ensuring quality delivery of product increments while minimizing disruption to operations.
BiotechnologyLife ScienceManufacturing
Responsibilities
Develop and own the periodic scheduled and unscheduled site downtime calendar. Negotiate maintenance windows with Manufacturing Leadership to balance system health with production targets
Synchronize release schedules across disparate systems to prevent conflicts. Specifically coordinate alignment between: SAP S/4 & EWM global releases, MES local updates and hotfixes, and Infrastructure Patching (OS, Database, Security) cycles
Lead the "Go/No-Go" decision process for all deployments. Manage detailed cutover plans, runbooks, and Return-to-Service activities to ensure production/packaging is possible immediately following downtime
Ensure that local site maintenance windows are aligned with the Global ITOT system landscape roadmap
Lead site-specific planning for Agile Product Increments. Translate global technical capabilities into local operational realities
Act as the Single Point of Contact for the Business Process Expert community. Prioritize new requirements and functional changes in the backlog to ensure local needs are represented in global S/4 Release Trains
Ensure, together with ITOT leadership, that expert teams are adequately resourced (budget, time) to execute the quarterly increment delivery
Orchestrate local and global testing efforts, specifically focusing on Interface Testing between SAP, MES, and Automation layers to ensure data integrity is maintained across the stack
Conduct impact assessments for incoming changes to determine risks to the production environment
Ensure validation documentation is complete prior to release
Proactively identify challenges that could threaten delivery timelines or site productivity. Develop workaround strategies and mitigation plans for critical risks
Manage vendor accountability during critical downtimes and patching cycles to ensure support availability
Lead technical cross-team coordination during the "Hypercare" phase post-deployment. Manage the resolution of defects and escalations to ensure a stable return to steady-state operations
Lead retrospectives and Post-Implementation Reviews to refine the downtime planning process and reduce lead times for future updates
Qualification
Required
Bachelor's degree in Computer Science, Automation Engineering, Business Informatics, or a related field
5–7 years of experience in manufacturing IT, Quality, or Supply Chain environments
Proven experience managing ERP (SAP S/4, EWM) and/or MES system lifecycles
Strong knowledge of ITIL (Release & Change Management) and Agile/SAFe methodologies
Experience coordinating end-to-end integration testing across distributed systems
Ability to communicate clear, precise technical information to non-technical business stakeholders and senior leadership
Experience working with global/remote teams and influencing decisions in a matrixed organization
Willingness to support deployments during planned downtimes (which may occur on weekends or off-hours, or holidays.)
Willingness to travel (international/domestic) up to 5%
Preferred
Experience working in a GMP/FDA regulated environment
Benefits
A discretionary annual bonus may be available based on individual and Company performance.
Company
Genentech
Genentech is a biotechnology research company that specializes in genetic testing and personalized medicines.
10001+ employees
H1B Sponsorship
Genentech has a track record of offering H1B sponsorships. Please note that this does not
guarantee sponsorship for this specific role. Below presents additional info for your
reference. (Data Powered by US Department of Labor)
Distribution of Different Job Fields Receiving Sponsorship
Represents job field similar to this job
Trends of Total Sponsorships
2025 (167)
2024 (148)
2023 (150)
2022 (178)
2021 (121)
2020 (158)
Funding
Current Stage
Public CompanyTotal Funding
unknown2009-03-26Acquired
1999-07-20IPO
1976-01-01Series Unknown
Leadership Team
Ashley Magargee
Chief Executive Officer
Michael Laird
Vice President, Global MSAT Drug Substance Biologics Technology and Commercial Products Support
Recent News
2026-01-23
Genetic Engineering News
2026-01-23
Company data provided by crunchbase