Iambic Therapeutics · 8 hours ago
Research Scientist II / Senior, Translational Biology
San Diego, CA
Full-time
Onsite
Mid, Senior Level
$125K/yr - $172K/yr
2+ years expIambic Therapeutics is seeking a highly motivated and collaborative Scientist to join our Translational Biology group and contribute to the discovery and development of small-molecule cancer therapeutics. This position plays a critical role in integrating in vitro and in vivo pharmacology, external CRO coordination, and mechanistic/translational research to advance pipeline programs.
Artificial Intelligence (AI)Machine LearningSoftwareTherapeutics
Responsibilities
Work closely with the Biology group/Project teams to design and develop translational studies for various programs
Design and manage in vivo pharmacology studies (PK/PD, efficacy, and toxicology with focus on oncology) at CROs
Design and execute hands-on experiments in cell and molecular biology, including: Cell proliferation and viability assays; ELISA, Western blot, qPCR, flow cytometry; Reporter and proximity-based assays (e.g., AlphaLISA, HTRF, NanoBRET)
Analyze and interpret data from internal experiments, CRO deliverables, and scientific literature to guide decision-making
Collaborate across functional teams to align experimental designs with project goals
Conduct literature reviews to support the mechanism of action, mechanism of resistance, and translational biomarker strategies
Present experimental results and project updates at internal team meetings
Qualification
Required
PhD in biochemistry, cell biology, cancer biology, pharmacology, or related discipline with at least 2 - 8 years of relevant academic or industry experience
MS with 7+ years of experience
BS with 9+ years of experience
Experience in cancer research, mechanism of action/resistance, or translational biomarker development
Hands-on experience in in vivo pharmacology, including designing and interpreting PK/PD and efficacy studies in oncology models, including combination studies
Familiarity with dosing strategies, route of administration, and biomarker collection (e.g., plasma, tumor tissues)
Oversight and coordination of in vivo studies at CROs, with ability to review protocols, QC data, and troubleshoot issues
Strong proficiency in cell and molecular biology, including cell culture, cell engineering, ELISA, Western blotting, qPCR, and flow cytometry
Experience developing and troubleshooting biochemical and cell-based assays to evaluate small molecule compounds
Ability to independently design experiments and analyze data to guide translational research objectives and early clinical development
Excellent communication skills and ability to work collaboratively across teams
Highly motivated to learn new technologies and contribute across multiple projects
Benefits
Company paid healthcare
Flexible spending accounts
Voluntary life insurance
401K matching
Uncapped vacation
Company
Iambic Therapeutics
Iambic is a clinical-stage life-science and technology company developing novel medicines using its AI-driven discovery and development platform.
51-200 employees
Funding
Current Stage
Growth StageTotal Funding
$303M2025-11-10Series Unknown· $100M
2024-04-24Series B· $50M
2023-10-03Series B· $100M
Leadership Team
Thomas Miller
Co-founder and CEO
Neil Josephson
Chief Medical Officer
Recent News
2025-12-16
2025-11-30
Company data provided by crunchbase