Frederick National Laboratory for Cancer Research · 1 day ago
Associate Scientist - Mass Spectrometry Proteomics
Frederick, MD
Full-time
Onsite
Senior Level, Lead/Staff
$94K/yr - $134K/yr
8+ years expFrederick National Laboratory for Cancer Research is dedicated to addressing urgent problems in biomedical sciences, particularly in cancer and AIDS. The Associate Scientist in Mass Spectrometry Proteomics will perform LC-MS-based proteomics experiments, maintain instrumentation, analyze data, and assist with lab operations while collaborating with other scientists.
BiotechnologyHealth CareMedicalOncology
No H1B
Security Clearance Required
Responsibilities
Work independently and collaboratively with scientists to perform liquid chromatography-mass spectrometry (LC-MS)-based proteomics experiments, including: protein extraction/digestion, solid-phase extraction (SPE), immunoaffinity enrichment, etc. following established SOPs
Help operate and maintain state-of-the-art LC-MS instrumentation (SCIEX 7500, Thermo TSQ Altis, Thermo Orbitrap Eclipse) and ensure high quality data generation for targeted proteomics
Perform comprehensive data analysis using a variety of methods and software, such as Skyline, Excel, R, Python, etc
Formally present data to team members and collaborators
Establish (design, test, and write) new or modify/optimize existing technical SOPs
Document experimental results in a reproducible manner
Assist with everyday lab operation, including but not limited to: maintaining lab inventories, ordering supplies, receiving packages, maintaining lab waste, facilitating engineer visits, communicating lab activities to supervisor, etc
Comply with all safety procedures, company policies, and established ways of work in the group
Qualification
Required
Possession of Bachelor's degree from an accredited college/university according to the Council for Higher Education Accreditation (CHEA) or four (4) years relevant experience in lieu of degree. Foreign degrees must be evaluated for U.S. equivalency
In addition to the education requirement, a minimum of eight (8) years of related experience is required
Both theoretical and hands-on experience in MS-based targeted (MRM and/or PRM) proteomics, including but not limited to: separation chemistry, sample preparation, LC-MS operation and troubleshooting, and data analysis
Experience with performing large scale studies that require precise preparation (i.e., for quantitative work)
Detail-oriented, highly-collaborative, self-motivated, and team-oriented
Excellent verbal and written communication skills
Ability to work on-site full time (8 hours/day, 5 days/week)
Ability to obtain and maintain a security clearance
Preferred
M.S. degree in biochemistry, analytical chemistry or other related discipline from an accredited college or university according to the Council for Higher Education Accreditation
6 years of related post graduate MS-based proteomic experience
Experience operating a SCIEX 7500 and/or Thermo TSQ Altis
Experience operating a Waters ACQUITY UPLC M-Class, and/or Thermo UltiMate nanoLC (i.e., microflow or nanoflow LC, respectively)
Experience with Skyline software
Experience with Covaris ultrasonicators and/or liquid handlers
Experience working with antibodies
Experience performing global proteomics experiments
Familiarity with CLIA requirements
Benefits
Competitive compensation
Health and Wellness programs
Income Protection
Paid Leave
Retirement
Company
Frederick National Laboratory for Cancer Research
Frederick National Laboratory for Cancer Research specializes in developing biomedical research and technology to improve human health.
1001-5000 employees
Funding
Current Stage
Late StageLeadership Team
Amanda Brooks
Talent Acquisition Partner
Betsy Day
Learning and Development Partner
Recent News
2025-10-14
2025-09-29
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