Sanofi · 3 hours ago
Clinical Digital & AI Acceleration Portfolio Manager
Cambridge, MA
Full-time
Onsite
Senior Level
7+ years expSanofi is a leading bio-pharmaceutical company committed to advancing healthcare through groundbreaking research and development. The Clinical Digital & AI Acceleration Portfolio Manager will orchestrate the end-to-end transformation portfolio, ensuring initiatives are prioritized and integrated to deliver tangible outcomes and measurable impact on clinical operations.
Health CareLife SciencePharmaceuticalTherapeutics
Responsibilities
Continuously align portfolio components with Sanofi’s strategy and CSO priorities, ensuring a clear line of sight between transformation investments and business outcomes
Shape and challenge the portfolio strategy by developing scenarios that support executive decision-making, trade-offs, and prioritization
Identify cross-initiative synergies, reuse opportunities, and integration levers to avoid siloed digital initiatives
Translate modernization ambitions (digital, data, AI) into executable, value-driven roadmaps
Actively identify new modernization opportunities across clinical operations, informed by performance data, capability gaps, and emerging technologies
Coordinate, evolve and professionalize the Initiative Portfolio Management Office (iPMO) as a strategic governance layer, not only a control mechanism
Define and maintain governance standards covering value hypotheses, ROI tracking, adoption readiness, and scale-up criteria
Coach and challenge program teams on business case quality, value articulation, and outcome-based delivery
Ensure alignment with Digital, eDEV, and CSO innovation governance, including integration of externally incubated or “off-the-shelf” solutions
Act as a modernization thought partner rather than a purely procedural PMO
Own the definition and consolidation of portfolio-level KPIs, including value realization, adoption, maturity, and transformation impact
Monitor portfolio health using decision-grade performance intelligence (progress, risks, interdependencies, value delivery)
Proactively identify risks, bottlenecks, and underperforming initiatives, and recommend corrective or reprioritization actions
Ensure robust transition to business and establish and maintain a framework for visibility of transition to business and scale-up, tracking whether initiatives deliver value beyond pilot phases
Produce executive-level insights and narratives linking digital transformation to tangible CSO outcomes
Manage complex transformation program as needed
Partner with Finance and OPCM to drive disciplined investment management across the portfolio
Ensure initiatives are supported by clear financial logic (ROI, cost avoidance, productivity gains, quality or cycle-time impact)
Track financial performance across the lifecycle, from investment decision to realized value
Support budget cycles and financial milestones with credible, evidence-based portfolio insights
Assess and consolidate portfolio-level resource needs, with a focus on critical capabilities rather than just capacity
Optimize resource allocation across initiatives to maximize portfolio throughput and value
Support vendor strategy, sourcing decisions, and contract governance in alignment with transformation priorities, and ensure up-to-date tracking of external resource allocation
Identify capability gaps (digital, data, AI, change) and propose targeted upskilling or sourcing solutions
Ensure coherent onboarding and enablement of teams across programs
Design and execute high-impact portfolio presentations, reports and communications for CSO leadership (SLT, deep dives, executive reviews, etc)
Act as a trusted interlocutor for MPO leader and senior stakeholders, balancing competing priorities and perspectives
Translate complex transformation topics into clear, outcome-oriented executive narratives
Deliver concise, insight-driven monthly portfolio reports highlighting progress, deployment, value, risks, and decisions required
Qualification
Required
Minimum 7+ years in project and portfolio management, with demonstrated exposure to large-scale transformation or modernization programs
Proven experience driving digital, data, or AI-enabled transformation in complex organizations
Strong command of portfolio governance, value-based prioritization, and performance tracking
Solid experience with business case development, ROI modeling, and financial steering
Demonstrated ability to partner with senior leaders and influence without direct authority
Experience in matrixed, global environments requiring orchestration across functions
Bachelors required
Preferred
Master's degree or PhD
Experience in digital audit
Benefits
High-quality healthcare
Prevention and wellness programs
At least 14 weeks’ gender-neutral parental leave
Company
Sanofi
Sanofi is a global biopharma company focused on prescription drugs, vaccines, and treatments for chronic, rare, and infectious diseases.
10001+ employees
H1B Sponsorship
Sanofi has a track record of offering H1B sponsorships. Please note that this does not
guarantee sponsorship for this specific role. Below presents additional info for your
reference. (Data Powered by US Department of Labor)
Distribution of Different Job Fields Receiving Sponsorship
Represents job field similar to this job
Trends of Total Sponsorships
2025 (101)
2024 (68)
2023 (59)
2022 (78)
2021 (38)
2020 (38)
Funding
Current Stage
Public CompanyTotal Funding
$6.97BKey Investors
Blackstone Life SciencesEvotec
2025-10-28Post Ipo Debt· $3B
2025-06-17Post Ipo Debt· $1.74B
2025-03-05Post Ipo Debt· $1.59B
Leadership Team
Paul Hudson
Chief Executive Officer
Francois-Xavier Roger
Chief Financial Officer
Recent News
2026-01-25
BioWorld Financial Watch
2026-01-25
2026-01-24
Company data provided by crunchbase