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Nucleo (YC F25) · 17 hours ago

Chief of Staff to CEO

San Francisco, CA

Full-time

Onsite

Mid, Senior Level

$60K/yr - $120K/yr

Nucleo is an early-stage, high-impact company backed by Y Combinator, seeking a Chief of Staff to work closely with the CEO. The role involves supporting the CEO in running the business, managing relationships, and overseeing various operational aspects to ensure the company's growth and success.

AnalyticsArtificial Intelligence (AI)Information TechnologyMachine Learning

Responsibilities

Partner closely (on a daily basis) with the CEO on all aspects of running the business

Support the CEO in prioritization, communications, and time allocation to ensure focus on the most critical initiatives

Run weekly exec cadences, project trackers, and help prep internal and external communications

Support go-to-market execution: sales ops, outbound campaigns, deal support

Manage and maintain relationships with hospital customers and partners

Support fundraising: investor pipeline, updates, and diligence prep

Keep visibility on company finances: expenses, vendors, basic accounting

Support regulatory execution (FDA / CE): timelines, documentation, coordination

Qualification

Business scalingSales operationsProject managementHealthcare experienceSaaS knowledgeExecution velocityDynamic environment managementWork ethic

Required

Proven track record of building/scaling a business/project. We don't care whether your background is business, technical, or something else

You are based in SF or willing to relocate within this year (we can support O-1)

You're willing to work in person and travel when needed

Proven ability to manage multiple priorities in a fast-paced, dynamic environment. Instinct for early-stage scrappiness & hustle

Strong work ethic & execution velocity

Preferred

Experience with hospitals, healthcare procurement, or medical sales

Background in, or passion for, SaaS, AI, or technology companies

Medical training (MD, med student, or formal education in medicine / biomedical sciences)

Benefits

0.50% - 1.50% equity

Company

Nucleo (YC F25)

We help oncologists and radiologists by automating medical imaging processing with machine learning.

Founded in 2025

San Francisco, California, USA

2-10 employees

https://nucleoresearch.com

Funding

Current Stage

Early Stage

Total Funding

$0.5M

Key Investors

Y Combinator

2025-12-03Pre Seed· $0.5M

Leadership Team

Angelica Iacovelli

CEO, Co-founder

Luca Pegolotti

Co-founder & CTO

Company data provided by crunchbase