Merck · 2 days ago
Senior Scientist, Pharmacology
Lansdale, PA
Full-time
Hybrid
Mid, Senior Level
$106K/yr - $167K/yr
2+ years expMerck is seeking a motivated and talented in vitro pharmacologist/physiologist with experience in the development and characterization of Novel Alternative Methods (NAMs) to support nonclinical safety pharmacology and functional toxicity assessments. The successful candidate will work within a collaborative environment to drive innovation and influence drug development strategy while complementing existing team expertise.
BiotechnologyHealth CareMedicalPharmaceutical
No H1B
Responsibilities
Ability to work both within teams as a contributor or as a team lead to drive collaborations across departments that deliver current needs and future capabilities
Development and/or utilization of exploratory hIPSC-derived models with a focus on functional, medium-throughput (plate-based) safety pharmacology endpoints to enable issue-driven resolution and complement preclinical candidate selection and development
Willingness and ability to investigate, develop and implement new technologies and capabilities to improve existing techniques and assays
Experience with the maintenance and culture of recombinant mammalian cell lines, iPSC-derived cells, and/or liquid handling
Qualification
Required
PhD with 2+ years relevant post-degree experience in the development, execution and interpretation of in vitro exploratory or regulated nonclinical safety pharmacology/toxicology models
Ability to work both within teams as a contributor or as a team lead to drive collaborations across departments that deliver current needs and future capabilities
Development and/or utilization of exploratory hIPSC-derived models with a focus on functional, medium-throughput (plate-based) safety pharmacology endpoints to enable issue-driven resolution and complement preclinical candidate selection and development
Willingness and ability to investigate, develop and implement new technologies and capabilities to improve existing techniques and assays
Experience with the maintenance and culture of recombinant mammalian cell lines, iPSC-derived cells, and/or liquid handling
Preferred
Experience in ion channel electrophysiology and its practical application in standard screening, regulatory required studies, and/or investigative models to understand potential effects of major organ systems
Prior experience working in a multidisciplinary environment within the Pharmaceutical Industry, Regulatory Agencies, or Academic Institutions
Willingness to influence safety pharmacology science and the broader regulatory landscape through active participation in external consortiums, publications, and presentations at key scientific conferences
Working knowledge of plate-based imaging assays and data analysis; proficiency in high content imaging and phenotypic in vitro assay development, multi-parametric computational image analysis, QC, visualization and computational modeling
Experience or familiarity with biostatistics, programming languages (examples Python or R), and/or data visualization tools
Benefits
Medical
Dental
Vision healthcare
Other insurance benefits (for employee and family)
Retirement benefits, including 401(k)
Paid holidays
Vacation
Compassionate and sick days
Company
Merck
Merck is a biopharmaceutical company that offers medicines and vaccines for various diseases.
10001+ employees
Funding
Current Stage
Public CompanyTotal Funding
$5.59MKey Investors
Private Capital Advisors"Gavi, the Vaccine Alliance"
2018-11-25Post Ipo Equity· $0.59M
2016-01-21Series Unknown· $5M
1980-12-19IPO
Leadership Team
Betty Larson
Executive Vice President and Chief Human Resources Officer
Dean Li
Executive Vice President and President, Merck Research Laboratories
Recent News
2026-02-04
Pharma Letter
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2026-02-03
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