Mass General Brigham · 11 hours ago
Research Fellow - Vascular Biology, Human Genetics, and Fibromuscular Dysplasia (FMD)
Boston-MA
Full-time
Hybrid
New Grad, Entry LevelMass General Brigham is a not-for-profit organization focused on patient care, research, teaching, and community service. They are seeking a highly motivated Postdoctoral Fellow to join a multidisciplinary research program aimed at understanding the genetic and molecular mechanisms of fibromuscular dysplasia and related conditions.
Health CareHome Health CareMedical
Responsibilities
Analyze and interpret human genetic data related to FMD, SCAD, and CeAD, including rare variant, common variant, and gene-burden analyses
Integrate human genetic findings with downstream cellular and in vivo functional studies
Design and execute experimental studies investigating vascular smooth muscle cell (VSMC) and extracellular matrix (ECM) dysfunction driven by genetically prioritized targets
Perform and analyze in vitro and ex vivo cellular models, including primary human VSMCs, iPSC-derived smooth muscle cells, and engineered vascular tissues
Apply genome engineering approaches (e.g., CRISPR/Cas9-based perturbations) to model human genetic variants and regulatory mechanisms
Contribute to murine models of arterial remodeling, vascular integrity, and sex-specific disease mechanisms
Prepare manuscripts, figures, and presentations for peer-reviewed publication and scientific meetings
Qualification
Required
PhD (or MD/PhD) in human genetics, cardiovascular biology, vascular biology, genomics, molecular biology, or a related field
Demonstrated experience in human genetics, including analysis or interpretation of genome-wide association studies (GWAS), whole-exome sequencing (WES), whole-genome sequencing (WGS), or rare-variant analyses
Strong background in cell and molecular biology, ideally with experience working with vascular smooth muscle cells or related cell types
Hands-on experience with one or more of the following: Genomic variant annotation and prioritization, CRISPR/Cas9 or other genome-editing approaches, iPSC culture and differentiation, Murine models of cardiovascular or connective tissue disease
Ability to work with complex datasets and translate human genetic findings into testable biological hypotheses
Strong written and verbal communication skills, with a record of or clear potential for peer-reviewed publication
Preferred
Experience integrating human genetic data with functional genomics or multi-omics datasets
Familiarity with statistical genetics, bioinformatics pipelines, or collaborative data analysis environments
Experience studying extracellular matrix biology, collagen remodeling, or arterial biomechanics
Interest in sex-specific genetic effects and vascular disease mechanisms
Company
Mass General Brigham
Mass General Brigham specializes in providing medical treatments and health diagnostics services.
Founded in 1994
10001+ employees
H1B Sponsorship
Mass General Brigham has a track record of offering H1B sponsorships. Please note that this does not
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2025 (77)
2024 (61)
2023 (93)
2022 (70)
2021 (80)
2020 (29)
Funding
Current Stage
Late StageLeadership Team
E
Erin Flanigan
SVP, Human Resources, Community, Specialty Hospital Division
O’Neil A. Britton
Chief Integration Officer, Executive Vice President
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