Maze Therapeutics · 21 hours ago
Director, Biostatistics
South San Francisco, CA
Full-time
Hybrid
Director/Executive
$228K/yr - $280K/yr
8+ years expMaze Therapeutics is a clinical-stage biopharmaceutical company focused on developing novel precision medicines for patients with renal and cardiovascular diseases. The Director of Biostatistics will lead biostatistical strategy and execution for clinical studies, ensuring robust and impactful data-driven results while collaborating with various cross-functional teams.
BiopharmaBiotechnologyGeneticsTherapeutics
Responsibilities
Serve as the biostatistics lead for clinical studies, providing expert input on study design, endpoints, and statistical strategy
Oversee and contribute to completion of all technical and operational statistical activities for a group of clinical trials. Ensure development and review of statistical analysis plans (SAPs), including complex and innovative methodologies
Collaborate with cross-functional partners in protocol development, study design discussions, and data interpretation
Partner with Statistical Programming to generate and validate analyses for internal use, publications, and regulatory submissions
Oversee CRO execution of statistical tasks: managing timelines, quality, and analytical approaches
Represent biostatistics in regulatory interactions (FDA, EMA, PMDA, etc.), contributing to briefing documents, meeting preparation, and responses to agency questions
Contribute to clinical study reports (CSRs), integrated summaries (ISS/ISE), and regulatory submissions (NDA/BLA/MAA)
Apply advanced statistical techniques to explore, analyze, and interpret clinical, safety, biomarker, and exploratory data
Advise internal and external partners on statistical approaches, data reliability, model selection, and interpretation of results
Lead the gathering, organization and analysis of different data sources to enable delivery of special projects and / or the statistical analysis plan and clinical study endpoints for assigned products
Review and analyze safety reporting, biomarker analyses and other aspects of clinical trial monitoring
Develop enhancements to statistical software, as appropriate, by programming new techniques; maintain knowledge of current and emerging trends in statistical analysis methodologies and tools
Provide biostatistical input into clinical development documentation, scientific publications and presentations, and regulatory documentation
Adhere to regulatory requirements of study conduct, statistical analysis principles, industry standards, and Maze SOPs
Support due diligence, licensing, and partnering activities as needed
Qualification
Required
An advanced degree in Biostatistics, Statistics, or a related field
Master's degree with 10+ years of experience, or Ph.D. with 8+ years of experience
Comfortable being hands-on with analysis, simulations, and document review
Direct experience designing early-stage trials (Phase I/II) and late-stage trials in resource-constrained settings
Confident decision-maker who can influence at the executive level
Collaborative, mentorship-oriented leadership style
This role follows a hybrid schedule, with an expectation to be onsite at our South San Francisco headquarters at least three days per week
Benefits
Competitive medical, dental, and vision insurance
Mental health offerings
Equity incentive plan
401(k) program with employer match
Generous holiday and PTO policy
Company
Maze Therapeutics
Maze Therapeutics is a biotechnology company that develops precision medicines for renal, cardiovascular, and metabolic diseases.
51-200 employees
H1B Sponsorship
Maze Therapeutics has a track record of offering H1B sponsorships. Please note that this does not
guarantee sponsorship for this specific role. Below presents additional info for your
reference. (Data Powered by US Department of Labor)
Distribution of Different Job Fields Receiving Sponsorship
Represents job field similar to this job
Trends of Total Sponsorships
2025 (2)
2024 (3)
2023 (2)
2022 (5)
2021 (3)
2020 (1)
Funding
Current Stage
Public CompanyTotal Funding
$646MKey Investors
Matrix Capital ManagementCity Hill Ventures
2025-09-11Post Ipo Equity· $150M
2025-01-31IPO
2024-12-03Series D· $115M
Leadership Team
Jason Coloma
Chief Executive Officer
Misbah Tahir
Chief Financial Officer
Recent News
General Catalyst
2026-01-13
2026-01-06
Maze Therapeutics, Inc.
2025-11-09
Company data provided by crunchbase