Flagship Pioneering · 18 hours ago
Director, Protein & Cell Sciences
Somerville, MA USA
Full-time
Onsite
Senior Level, Lead/Staff
$183K/yr - $231K/yr
10+ years expMetaphore Bio is a generative AI drug design company focused on creating a new class of functional antibodies. The Director of Protein & Cell Sciences will lead a team responsible for the production and characterization of therapeutic proteins, ensuring high-quality delivery for biologics discovery programs and optimizing discovery platforms.
FinanceFinancial ServicesVenture Capital
Responsibilities
Lead an engaged and entrepreneurial team of 4-5 scientists that contributes significantly to the advancement of the internal and partnered portfolio, develops novel platforms and techniques, and delivers well-characterized, high-quality development candidates
Establish, maintain, and communicate best practices for biochemistry and cell biology techniques including expression, production, purification, and analytical and functional characterization of antibodies and related therapeutic proteins
Ensure high quality data management including the use of electronic laboratory environments/LIMS for data storage and retrieval, to maximize the potential of AI/ML methods to deliver high-quality leads
Partner with research informatics and laboratory automation teams to identify and implement opportunities for improved workflows, more efficient protein production and characterization, and parallelized therapeutic discovery
Make highly impactful contributions to programs as a scientific leader and expert on protein therapeutics
Implement and manage outsourced protein production and characterization work with CROs that complements internal resourcing
Serve as a major interface with downstream CMC functions and external CDMOs to enable seamless progression of molecules into and through DC nomination, process development, and early manufacturing
Accountable for resourcing decisions for programs within the HTPP function
Partner with peers on the Biotherapeutics leadership team to manage resources, budgets, and operations
Recruit, mentor, and develop a high-performing HTPP unit
Foster a culture of collaboration, innovation, and accountability by partnering with other functions within the Biotherapeutics unit and across Metaphore
Partner with external collaborators, CROs, and technology providers to expand capabilities and accelerate timelines
As a member of the Biotherapeutics leadership team, facilitate group operations and strategic decisions, contribute to the development of the culture and people within the group, and contribute to broader company-wide strategic initiatives
Qualification
Required
PhD in Protein Biochemistry, Molecular and Cell Biology, Structural Biology, or a related discipline, or non-PhD with appropriate skills and experience
10+ years of experience in biologics drug discovery and development
Deep knowledge of antibody expression, purification, and characterization workflows, including the implementation of automation solutions to enable high-throughput protein production
Experience managing biologics CROs to expand protein production/characterization capabilities and capacity
Strong interpersonal and communication skills, with an established track record of leading and developing people and teams in a fast-paced, entrepreneurial biotech environment
Benefits
Healthcare coverage
Annual incentive program
Retirement benefits
Broad range of other benefits
Company
Flagship Pioneering
Flagship Pioneering is a venture capital firm that invests in life sciences and healthcare companies.
501-1000 employees
H1B Sponsorship
Flagship Pioneering has a track record of offering H1B sponsorships. Please note that this does not
guarantee sponsorship for this specific role. Below presents additional info for your
reference. (Data Powered by US Department of Labor)
Distribution of Different Job Fields Receiving Sponsorship
Represents job field similar to this job
Trends of Total Sponsorships
2025 (8)
2024 (4)
2023 (4)
2022 (4)
2021 (1)
Funding
Current Stage
Late StageLeadership Team
Noubar Afeyan
Founder and CEO
Chuck Carelli
Chief Financial Officer
Recent News
2026-01-16
2026-01-16
Company data provided by crunchbase