Calico Life Sciences · 4 hours ago
Principal Associate Scientist, Biomarkers
South San Francisco, CA
Full-time
Onsite
Lead/Staff
$163K/yr - $172K/yr
14+ years expCalico is a research and development company focused on understanding human aging and promoting healthier lives. They are seeking a Principal Associate Scientist to lead biomarker discovery and validation efforts for clinical programs in Neuroscience, Oncology, and Aging-related diseases.
Biotechnology
Responsibilities
Discover and validate pharmacodynamic biomarkers to support the clinical development of drugs with novel MoAs utilizing pre-clinical models (in vivo and in vitro) and human specimens
Lead the development, optimization, and qualification of biomarker assays using various platform
Perform rigorous analysis to establish PK/PD relationships and benchmark program compounds
Utilize statistical and specialized tools to interpret results from ex-vivo and in-vitro studies, delivering actionable insights for clinical dose selection
Synthesize complex biological data into clear reports and strategic guidance for senior management
Oversee the technical transfer of validated assays to CROs or internal bioanalysis teams for Phase I/II studies
Curate and analyze competitive intelligence to inform discovery strategy and provide scenario assessments of high-priority clinical assets
Manage and mentor junior scientists, fostering a culture of technical excellence and scientific curiosity
Qualification
Required
BS or MS degree in cell biology, molecular biology, neuroscience, or a related field, with 14+ years of industry experience
Well-versed in a wide range of molecular biology, biochemistry, and cell biology techniques, including RNA isolation, qPCR, Western blotting, and immunoprecipitation
Significant experience in the extraction of soluble, insoluble, and aggregated proteins and subcellular fractionation
Extensive hands-on experience in primary and immortalized cell culture, including the processing of human whole blood for PBMC and specific immune cell isolation as well as ex-vivo stimulation of whole blood or PBMCs
Expert-level proficiency in high-sensitivity and multiplex platforms such as Olink, MSD, SIMOA, NULISA, and SOMAscan
Strong data analysis proficiencies with strong preference for proficiency in data science programming languages such as R or Python for both statistical analysis and visualization
Self-motivated with a 'can-do' attitude, able to troubleshoot experiments independently, and possessing strong teamwork and communication skills
Must be willing to work onsite 5 days a week
Benefits
This position is also eligible for two annual cash bonuses.
Company
Calico Life Sciences
Calico is an Alphabet-founded research and development company whose mission is to harness advanced technologies.
201-500 employees
H1B Sponsorship
Calico Life Sciences has a track record of offering H1B sponsorships. Please note that this does not
guarantee sponsorship for this specific role. Below presents additional info for your
reference. (Data Powered by US Department of Labor)
Distribution of Different Job Fields Receiving Sponsorship
Represents job field similar to this job
Trends of Total Sponsorships
2025 (12)
2024 (12)
2023 (7)
2022 (10)
2021 (5)
2020 (14)
Funding
Current Stage
Growth StageLeadership Team
Ashley Archuleta
Sr. Administrative Assistant to the Chief Business Officer
Jonathan Lewis
Chief Business Officer
Recent News
Research & Development World
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2025-11-15
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