Broad Institute of MIT and Harvard · 4 hours ago
Research Scientist II - Surfaceome Target Discovery And Biotherapeutic Development
Cambridge, MA
Full-time
Onsite
Mid, Senior Level
$100K/yr - $140K/yr
3+ years expThe Broad Institute of MIT and Harvard is the world's leading biomedical research institute dedicated to using genomics to transform the understanding and treatment of disease. The company is seeking a highly motivated Scientist to lead projects focused on discovering novel therapeutic antibodies and overseeing biological validation workflows, ensuring clinical potential for candidates.
BiotechnologyClinical TrialsLife Science
Responsibilities
Validate surface target expression using techniques such as flow cytometry, immunofluorescence, western blotting, and other relevant assays
Lead the biology components for antibody and other large molecule discovery and validation projects
Engineer bispecific proteins using a range of platforms and technologies, with an emphasis on improving efficacy, stability, and optimizing biotherapeutic formats (e.g. ADC, ADCC)
Perform molecular design, construct generation, and DNA and vector engineering using state-of-the-art software and tools
Expression and purification of engineered proteins using mammalian and microbial expression systems
Conduct/collaborate biophysical and functional characterization (e.g., SPR/BLI, HPLC, ELISA, MS) to evaluate binding kinetics, stability, and conformational integrity
Collaborate with assay development teams to establish in vitro and in vivo systems for functional evaluation of bispecific candidates
Supervise work executed through CROs
Cross-functional Collaboration: Work closely with the center for the development of therapeutics, oncology, and translational science teams to guide therapeutic discovery and preclinical development
Pipeline Contribution: Support integration of bispecific antibody candidates into the pipeline, providing data and strategic insights for IND-enabling studies
Leadership & Mentorship: Lead scientific initiatives, manage project timelines, and mentor junior scientists or research associates
Manage and mentor Research Associates
Identify and pursue opportunities for platform expansion and innovation
Qualification
Required
Ph.D. in Cancer Biology, Immunology, Cell Biology, Molecular Biology, or related fields is required
At least 3 years of post-graduate professional technical experience in a research environment
Strong scientific expertise in target biology and therapeutic target validation, with the ability to translate biological insights into actionable discovery strategies
Proven expertise in antibody discovery, engineering and characterization
Familiarity with antibody optimization techniques, including display technologies (e.g., phage, yeast, or mammalian)
Hands-on experience with modern molecular biology techniques, protein engineering, and structure-guided design
Demonstrated proficiency in protein expression, purification, and characterization techniques
Strong problem-solving and analytical skills, with attention to detail and data interpretation
Excellent communication and presentation skills to effectively convey scientific findings and project updates
Excellent organizational and time management skills with strong attention to detail
Ability to work independently and collaboratively in a multidisciplinary environment
Preferred
Familiarity with antibody-drug conjugates (ADCs), T-cell engagers, or other immune-based therapeutic modalities is a plus
Proficiency in data analysis software (e.g., Prism, MATLAB, PyMOL) and molecular biology tools (e.g., SnapGene, Geneious)
Experience in developing, managing, and mentoring junior scientists is a plus
Benefits
Medical
Dental
Vision
Life
Disability insurance
A 401(k) retirement plan
Flexible spending and health savings accounts
At least 13 paid holidays
Winter closure
Paid time off
Parental and family care leave
An employee assistance program
Among other Broad benefits
Company
Broad Institute of MIT and Harvard
The Broad Institute brings together a diverse group of individuals from across its partner institutions — undergraduate and graduate students, postdoctoral fellows, professional scientists, administrative professionals, and academic faculty.
1001-5000 employees
H1B Sponsorship
Broad Institute of MIT and Harvard has a track record of offering H1B sponsorships. Please note that this does not
guarantee sponsorship for this specific role. Below presents additional info for your
reference. (Data Powered by US Department of Labor)
Distribution of Different Job Fields Receiving Sponsorship
Represents job field similar to this job
Trends of Total Sponsorships
2025 (108)
2024 (59)
2023 (73)
2022 (68)
2021 (70)
2020 (93)
Funding
Current Stage
Late StageTotal Funding
$283.25MKey Investors
MacArthur FoundationAlzheimer's Foundation of AmericaMassachusetts Life Sciences Center
2025-11-18Grant· $100M
2020-08-11Grant
2019-09-09Grant· $0.75M
Leadership Team
Dan Shore
Chief Financial Officer
Anne Carpenter
Institute Scientist and Imaging Platform Senior Director
Recent News
Research & Development World
2026-01-22
Broad Institute of MIT and Harvard
2026-01-17
2025-12-02
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