Rhapsogen, Inc. · 18 hours ago
Vice President, Translational Science
Cambridge, MA
Full-time
Onsite
Director/Executive
15+ years expRhapsogen, Inc. is a biotechnology company based in Cambridge, MA, focused on developing precision biologics for IgG-mediated autoimmune diseases. They are seeking a Vice President of Translational Science to lead the strategy for CU43, ensuring the transition from discovery-stage biology to clinically actionable hypotheses and biomarkers.
BiotechnologyHealth CareManufacturing
Responsibilities
Own the translational strategy for CU43 from late discovery through early clinical stages
Partner closely with the VP of Research & Early Development to ensure seamless progression from discovery biology to translational hypotheses
Define, develop, and validate mechanism-based biomarkers and assays in autoimmune clinical indications
Lead dose and exposure rationale, integrating preclinical PK/PD, modeling, and human translational data
Ensure preclinical, ex vivo, and human-relevant datasets are hypothesis-driven, clinically relevant, and decision-enabling
Translate mechanistic insights into clear development logic, including indication prioritization and go/no-go criteria
Serve as the internal scientific authority on IgG biology, Fc receptor function, and antibody effector mechanisms
Support regulatory interactions by providing mechanistic and translational justification for development plans
Lead external translational collaborations with academic partners, CROs, and KOLs
Build, mentor, and scale the translational science function as the organization grows
Contribute to investor, partner, and board communications, clearly articulating CU43’s translational rationale and differentiation
Qualification
Required
Deep expertise in IgG biology, Fc receptor signaling, antibody effector mechanisms, or immune-mediated disease
Proven success translating discovery biology into early human proof-of-concept
Strong experience in biomarker strategy, PK/PD integration, and dose justification
Demonstrated ability to partner effectively with discovery and early development leaders
Experience operating successfully in early-stage or high-accountability biotech environments
Clear, persuasive communicator with scientific, regulatory, and investor audiences
Strategic mindset with hands-on scientific depth
Excellent verbal and written communication skills
Excellent organizational skills and attention to detail
PhD in immunology, translational medicine, or related discipline
15–18+ years of industry experience in translational science, with demonstrated leadership at the executive or near-executive level
Company
Rhapsogen, Inc.
Rhapsogen is a biotechnology company developing precision biologics for IgG-mediated autoimmune diseases.
2-10 employees
Funding
Current Stage
Early StageLeadership Team
Renato Skerlj
President and CEO
Recent News
2026-01-11
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