Breakout Ventures · 8 hours ago
Scientist
Cambridge, MA
Full-time
Onsite
Mid Level
$110K/yr - $135K/yrBreakout Ventures is a VC-backed biotech startup focused on gene therapy delivery platforms. They are seeking a Scientist to lead and grow their research engine, collaborating with technical leadership and managing research efforts across multiple programs.
Advanced MaterialsEnergyFinancial ServicesLife ScienceVenture Capital
Responsibilities
Support the Director of Research, Sr. Director of Platform Development, and R&D team in managing, coordinating, and supporting the research efforts across multiple collaborative research programs
Contribute to, and lead as required, R&D efforts to meet project milestones, maintaining the standards of scientific rigor and adhering to ethical standards
Maintain standards consistent with company culture and values
Work closely with team members (internal and external) to maintain project development, implementation and troubleshooting of experiments, and ensure deliverables for both internal research projects and external scientific partnerships
Generate, analyze, interpret, and share experimental results and ensure that all protocols, reagents, data, and analyses are documented following data integrity principles and prepared and made available in a timely manner
Attend and present at team meetings to share results, and plan projects and experiments, with a keen eye for achieving company milestones
Maintain comprehensive and up-to-date knowledge of extracellular vesicle biology, extracellular vesicles as therapeutics, and novel genetic engineering approaches
Perform other duties as assigned, including all those associated with facilitating the smooth operation of a wet lab environment
Qualification
Required
Ph.D. in molecular biology, hematology, immunology, bioengineering, or related field; strong background in genetic engineering/gene therapy (primary cells/hematopoietic lineages a plus)
Experience in in vitro, ex vivo, and in vivo studies assessing gene delivery, editing, and expression
Solid working knowledge of genome editing tools (CRISPR, TALEN, ZFNs) and therapeutic editing in preclinical models
Strong bench skills in molecular/cell biology (qPCR, RT-PCR, Western, microscopy, multiplex flow cytometry)
Experience designing/handling DNA & mRNA molecules; exposure to construct design and NGS workflows preferred
Experience with non-viral delivery systems (viral vectors, LNPs, EVs) and associated analytics
In vivo experience including vivarium work and animal model handling
Familiarity with electronic lab notebooks (ELNs) preferred
Experience collaborating with CROs/external partners; CMC familiarity a plus
Excellent communicator, highly organized, detail-oriented, collaborative
Proficient in Microsoft Office (Excel, PowerPoint) for data analysis/presentation
Preferred
Experience designing/handling DNA & mRNA molecules; exposure to construct design and NGS workflows preferred
Familiarity with electronic lab notebooks (ELNs) preferred
Experience collaborating with CROs/external partners; CMC familiarity a plus
Bonus: experience with startup ops, grant writing, or early product development
Company
Breakout Ventures
Breakout Ventures is an early stage fund that backs bold scientist entrepreneurs.
Founded in 2016
2-10 employees
Funding
Current Stage
Early StageTotal Funding
unknown2018-01-01Seed
Leadership Team
Dana Watt
Partner
Julia Moore
Managing Partner
Recent News
2025-04-16
2025-04-16
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