PineTree Therapeutics Inc · 4 hours ago
Director / Senior Director, Discovery & Investigative Toxicology (Multispecific Antibodies)
Cambridge, MA
Full-time
Onsite
Director/Executive
10+ years expPineTree Therapeutics Inc is seeking a Director or Senior Director of Discovery & Investigative Toxicology to provide scientific leadership in early safety assessment and mechanism-based toxicology for their bispecific/multispecific antibody discovery portfolio. The role focuses on identifying and mitigating safety risks early in the discovery stage and requires collaboration with various teams to ensure effective candidate selection and risk assessment.
BiotechnologyMedicalOncologyTherapeuticsWellness
Hiring Manager
Greg Shin
Responsibilities
Serve as the toxicology and safety biology lead for discovery-stage multispecific antibody programs
Identify and assess modality-specific safety risks, including:
Exaggerated or non-linear pharmacology
Receptor cross-linking and pathway overactivation
On-target/off-tumor effects
Species-dependent target biology
Design and oversee non-GLP, hypothesis-driven in vivo studies to interrogate safety mechanisms and inform candidate selection
Lead the design and deployment of early in vitro toxicology and safety screening strategies tailored to multispecific antibody formats
Define and apply fit-for-purpose in vitro assays to evaluate:
Target cross-reactivity and tissue binding
Exaggerated functional activity
Cytokine release and immune activation risk
Cell viability and pathway perturbation
Partner with Protein Engineering and Discovery teams to use in vitro findings to guide molecule design, format selection, and lead optimization
Integrate in vitro and in vivo data to develop mechanism-based mitigation strategies and decision criteria
Collaborate with DMPK/PK scientists to interpret exposure-driven safety signals common to bispecific/multispecific antibodies
Assess the impact of target-mediated drug disposition, tissue sinks, and avidity effects on early safety findings
Support early human risk thinking without owning formal FIH dose justification
Apply deep understanding of species biology, target expression, and cross-reactivity to:
Select appropriate models
Interpret non-classical findings
Anticipate human relevance
Translate early findings into clear, decision-enabling risk assessments for discovery and portfolio teams
Provide an independent safety perspective during candidate nomination and portfolio reviews
Clearly communicate uncertainty, confidence, and assumptions in early data
Support transition planning as programs move toward IND-enabling development
Establish best practices for discovery toxicology and early safety screening in an outsourced biotech model
Mentor discovery-stage scientists and contribute to a culture of rigorous, mechanism-based decision making
Stay current on emerging approaches, including NAMs, where scientifically appropriate
Qualification
Required
PhD, DVM, PharmD, or equivalent advanced degree in toxicology, pharmacology, pathology, or a related discipline
10+ years of experience in discovery and investigative toxicology, preferably with biologics
Demonstrated expertise in mechanism-based safety assessment and early risk mitigation
Hands-on experience designing or applying in vitro toxicology or safety screening assays
Strong understanding of multispecific antibody biology and liabilities
Ability to operate effectively in data-limited, early discovery environments
Preferred
Experience supporting later-stage project toxicology and/or GLP toxicology assessments for biologics
Familiarity with regulatory expectations for toxicology programs, particularly for antibodies
Veterinary training (DVM) and/or board certification (DACVP, DABT)
Oncology and/or immunology program experience
Company
PineTree Therapeutics Inc
Pinetree Therapeutics is an award-winning, pre-clinical stage biotechnology company based in Cambridge, Massachusetts.
11-50 employees
H1B Sponsorship
PineTree Therapeutics Inc has a track record of offering H1B sponsorships. Please note that this does not
guarantee sponsorship for this specific role. Below presents additional info for your
reference. (Data Powered by US Department of Labor)
Distribution of Different Job Fields Receiving Sponsorship
Represents job field similar to this job
Trends of Total Sponsorships
2024 (1)
2022 (1)
2021 (1)
2020 (2)
Funding
Current Stage
Growth StageTotal Funding
$87.5MKey Investors
Massachusetts Life Sciences Center
2025-10-28Series B· $47M
2024-07-30Series A· $17M
2022-09-27Grant
Leadership Team
Ho-Juhn Song
CEO/Founder
Recent News
2026-01-14
2025-11-01
Company data provided by crunchbase