4D Molecular Therapeutics · 19 hours ago
Senior Manager, Data Management
Emeryville, California
Full-time
Onsite
Senior Level
$178K/yr - $208K/yr
7+ years exp4DMT is a leading late-stage biotechnology company advancing durable and disease-targeted therapeutics. The Senior Manager, Data Management leads end-to-end clinical data management activities for assigned studies, ensuring high-quality clinical trial data delivery and providing operational oversight to internal staff and external vendors.
BiotechnologyGenetics
Responsibilities
Manage end‑to‑end Data Management activities for one or more clinical studies with moderate guidance from line manager
Oversee daily study‑level data management operations, ensuring compliance to timelines, quality standards, and SOPs
Support vendor oversight activities, including reviewing timelines, deliverables, and quality metrics
Contribute to risk identification and mitigation strategies for data‑related issues
Review study protocols to ensure appropriate data capture elements and eCRF design
Support the development of eCRF specifications and contribute to review of data requirements
Assist in coordinating EDC system design, testing, and UAT, ensuring adherence to company standards
Contribute and/or author Data Management Plans, Data Transfer Plans, and other study‑related documents
Support review of clinical monitoring plans, SAPs, and vendor specifications
Monitor data quality and cleaning activities, including management of data listings and reconciliation efforts
Partner with CROs and external vendors to ensure timely and high‑quality data deliverables
Participate in study team meetings, providing updates on Data Management metrics and timelines
Escalate issues appropriately to line manager, data management leadership or other functional leads
Oversee reconciliation activities (e.g., header data, SAE reconciliation) performed by CROs
Support database upgrades and migrations, including contribution to UAT
Participate in database snapshot, lock, and freeze activities
Provide day‑to‑day guidance and mentorship to Data Managers
Deliver training to internal and external team members on EDC systems or eCRF completion guidelines as needed
Maintain Data Management documentation and eTMF files
Other duties assigned: nothing in this job description restricts management’s right to assign or reassign duties and responsibilities to this job at any time
Qualification
Required
B.A./B.S. degree or higher (life-science-related fields preferred) or equivalent experience
7+ years of data management experience in the biotech/pharmaceutical industry or clinical data management service providers of which at least three (3+) years in a lead study data manager role
Experience with Phase 1-3 clinical trials required: retina diseases and/or gene therapies experience a plus
Demonstrated experience in vendor oversight and cross‑functional team leadership
Experience in vendor management and performance assessments
In-depth knowledge and experience with CDISC data standards and models
Proficient in using clinical data management systems (e.g., Medidata Rave) and the data flow, including those from external sources (IRT, safety, central/specialty labs, reading centers, PROs, etc.)
Proficiency in data management process and knowledge of Good Clinical Data Management Practices (GCDMP) in global clinical trials
Knowledge of ICH GCP and other applicable regulatory rules and guidelines
Knowledge of the clinical development process
Proficient with MS Office (Word, Excel, PowerPoint, etc.)
Strong communication and interpersonal skills (written and verbal)
Collaborative mindset with ability to work effectively
High attention to detail with excellent organizational and time‑management capabilities
Ability to manage multiple projects in a fast-paced environment
Proven conceptual, analytical and strategic thinking
Excellent attention to details
Company
4D Molecular Therapeutics
4D Molecular Therapeutics designs, develops, and commercializes transformative gene therapeutic products for unmet medical conditions.
51-200 employees
H1B Sponsorship
4D Molecular Therapeutics has a track record of offering H1B sponsorships. Please note that this does not
guarantee sponsorship for this specific role. Below presents additional info for your
reference. (Data Powered by US Department of Labor)
Distribution of Different Job Fields Receiving Sponsorship
Represents job field similar to this job
Trends of Total Sponsorships
2025 (1)
2024 (3)
2023 (1)
2022 (1)
2021 (4)
Funding
Current Stage
Public CompanyTotal Funding
$702.5MKey Investors
Cystic Fibrosis FoundationViking Global Investors
2025-11-06Post Ipo Equity· $100M
2025-10-13Post Ipo Equity· $7.5M
2024-02-06Post Ipo Equity· $300M
Leadership Team
David Kirn
Co-Founder & CEO
L
Liansheng Zhu
Sr VP Biometrics and Data Quality
Recent News
2026-01-07
Longevity.Technology - Latest News, Opinions, Analysis and Research
2025-12-19
Benzinga.com
2025-12-19
Company data provided by crunchbase