Alnylam Pharmaceuticals · 10 hours ago
Principal Scientist, Biology
Cambridge, MA
Full-time
Onsite
Senior Level, Lead/Staff
$147K/yr - $221K/yr
10+ years expAlnylam Pharmaceuticals is a leader in RNAi therapeutics, seeking a highly motivated scientific leader for their Next Wave, Target Discovery and Validation team. The role involves identifying unmet medical needs, validating therapeutic targets, and collaborating with various teams to shape the future of RNAi medicines.
BiotechnologyHealth CareMedicalPharmaceuticalTherapeutics
Responsibilities
Identify areas of unmet medical need and initiate target identification workflows in collaboration with statistical geneticists and translational science teams
Design and execute in vitro and in vivo studies to validate candidate targets and elucidate underlying molecular and physiological mechanisms of action
Analyze, interpret, and present scientific data at internal meetings and contribute to strategic planning discussions
Lead collaborations with external partners, CROs, and academic institutions, including project strategy, experimental design, planning, data interpretation, and decision-making
Communicate effectively and collaborate with key stakeholders across the organization
Manage and mentor junior scientists and associate scientist
Qualification
Required
PhD in biology or a related biomedical field with >10 years of postdoctoral experience and a strong record of high-quality publications
>5 years of biotech/pharma industry experience with a solid understanding of the drug development process
Successful candidates must demonstrate strong scientific curiosity, flexible mindset, and passion for learning and applying knowledge across diverse therapeutic areas, biological pathways, tissues/cell types, and therapeutic modalities
Proven expertise in developing and characterizing in vitro, ex vivo, and in vivo models, with a deep understanding of disease biology, pathogenesis, and mechanisms of action
Experience in interpreting human genetics analyses (e.g., GWAS, PheWAS, Mendelian randomization, eQTL/pQTL/sQTL) to inform therapeutic target discovery is required
Experience designing and executing experiments to validate genetic variants and their biological consequences is a strong plus
Candidates with a neuroscience background are encouraged to apply
Thrives in a fast-paced team environment with excellent written and verbal communication skills
Benefits
Comprehensive benefits including medical, dental, and vision coverage
Life and disability insurance
A lifestyle reimbursement program
Flexible spending and health savings accounts
A 401(k) with a generous company match
Paid time off
Wellness days
Holidays
Two company-wide recharge breaks
Generous family resources and leave
Company
Alnylam Pharmaceuticals
Alnylam Pharmaceuticals is a biopharmaceutical company focused on the discovery, development and commercialization.
1001-5000 employees
H1B Sponsorship
Alnylam Pharmaceuticals has a track record of offering H1B sponsorships. Please note that this does not
guarantee sponsorship for this specific role. Below presents additional info for your
reference. (Data Powered by US Department of Labor)
Distribution of Different Job Fields Receiving Sponsorship
Represents job field similar to this job
Trends of Total Sponsorships
2022 (18)
2021 (19)
2020 (7)
Funding
Current Stage
Public CompanyTotal Funding
$4.55BKey Investors
Blackstone Life SciencesBlackstone CreditRegeneron
2025-09-09Post Ipo Debt· $661.25M
2022-09-12Post Ipo Debt· $900M
2022-03-04IPO
Leadership Team
Yvonne Greenstreet
Chief Executive Officer
Jeff Poulton
Chief Financial Officer
Recent News
Clinical Trials Arena
2026-01-16
Longevity.Technology
2026-01-14
Company data provided by crunchbase