Novo Nordisk · 9 hours ago
Principal Scientist - Toxicology
Lexington, MA
Full-time
Onsite
Senior Level, Lead/Staff
$148K/yr - $260K/yr
8+ years expNovo Nordisk is a leading company in life science innovation, focused on developing new medicines for patients. The Principal Scientist in Toxicology will pioneer the strategy for small molecule early safety assessments and collaborate with global teams to ensure safety evaluations are integrated into drug discovery processes.
BiotechnologyHealth CareMedicalPharmaceutical
Responsibilities
Initiating, monitoring and reporting Exploratory Toxicology studies/data
Supervise the execution of in silico, in vitro and in vivo toxicology studies at CROs/technology providers to assess safety profiles and progress chemical leads
Identify and secure optimal exploratory toxicology screening plans in alignment with a cross-functional team including chemists, biologists, and ADME scientists to secure a customized lead optimization process (design, make, test, analyze)
Analyze, interpret and contextualize data to inform safety assessments and decision-making
Lead, support, and develop the Small Molecule Exploratory Toxicology Strategy Implementation in close collaboration with global colleagues
Follow the development of the field of exploratory toxicology at industry peers, CROs and technology providers
Ensure alignment with relevant industry standards, GxP requirements and regulatory standards
Collaborate with cross-functional teams to integrate Exploratory Toxicology strategies into broader drug discovery and development plans
Support Due Diligence (DD) processes
Assess potential assets based on available safety related information and drug-ability and advise decision making based on data and possible follow-up strategies in collaboration with global DD teams
Provide expert advisory functions on Exploratory Toxicology/non-clinical safety matters to relevant colleagues and stakeholders
Mentor and guide colleagues in developing their expertise in Exploratory Toxicology/non-clinical safety
Identify and solve complex safety-related challenges using a broad drug discovery and drug development perspective
Recommend innovative solutions and best practices to improve the Exploratory Toxicology/safety evaluation processes
Stay abreast of industry trends and advancements to maintain cutting-edge expertise
Qualification
Required
Master's degree with 12+ years of relevant experience, or PhD with 8+ years of relevant experience required
Proven industry expertise in small molecule exploratory toxicology, successfully delivering industry standard clinical candidates based on cross discipline lead optimization
Medicinal chemistry subject matter expertise is key to assess inherent molecular toxicity risks and to foster close discussion with project chemists
Experience working with cross functional teams and proven ability to communicate findings/results to non-SMEs
Solves complex safety problems with a broad perspective, identifying innovative solutions to promote project progression
Assess, evaluate and implement new in vitro and in vivo methods relevant for non-clinical safety evaluation/prediction
Communicates evaluations and implications of non-clinical safety findings effectively
Acts as a mentor for colleagues, fostering expertise within the organization
Preferred
Strong background with in vitro assays and in silico analysis is advantageous
Experience with predictive toxicity SAR tools (e.g. DEREK) is an advantage
Experience in regulatory toxicology and understanding of ICH guidelines is advantageous
Benefits
Medical, dental and vision coverage
Life insurance
Disability insurance
401(k) savings plan
Flexible spending accounts
Employee assistance program
Tuition reimbursement program
Voluntary benefits such as group legal, critical illness, identity theft protection, pet insurance and auto/home insurance
Time off pursuant to its sick time policy
Flex-able vacation policy
Parental leave policy
Company
Novo Nordisk
Novo Nordisk is a healthcare company that produces and distributes insulin and other diabetes drugs to treat chronic diseases.
10001+ employees
H1B Sponsorship
Novo Nordisk has a track record of offering H1B sponsorships. Please note that this does not
guarantee sponsorship for this specific role. Below presents additional info for your
reference. (Data Powered by US Department of Labor)
Distribution of Different Job Fields Receiving Sponsorship
Represents job field similar to this job
Trends of Total Sponsorships
2025 (25)
2024 (21)
2023 (13)
2022 (10)
2021 (9)
2020 (12)
Funding
Current Stage
Public CompanyTotal Funding
$22M2018-12-05Post Ipo Equity· $22M
1981-07-09IPO
Leadership Team
Lars Fruergaard Jørgensen
President and CEO
Lars Sorensen
President & CEO
Recent News
2026-02-04
2026-02-04
Markets | Mail Online
2026-02-04
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