The University of Georgia · 5 hours ago
Sr. Research Associate
Athens, GA
Full-time
Onsite
Senior Level
5+ years expThe University of Georgia is the state's flagship university, recognized for its commitment to higher education. The Sr. Research Associate will work on research projects focused on glycosaminoglycan biosynthesis regulation in human diseases, developing genomic and chemical biology tools to investigate glycosylation mechanisms.
Artificial Intelligence (AI)Information TechnologyRoboticsSoftware
No H1B
Responsibilities
Generating and characterizing CRISPR-mediated knock-out and knock-in cell lines for downstream screening assays and analysis of glycosylation pathways
Lead the design, execution, and optimization of CRISPR/Cas9-based genome engineering strategies, including knock-out, knock-in, and endogenous tagging approaches in mammalian cell lines
Independently design guide RNAs, donor templates, and cloning strategies for precise genome editing of glycosylation-related genes and pathways
Oversee and execute clonal isolation, genotyping, and molecular validation of edited cell lines using PCR, sequencing, immunoblotting, and functional assays
Develop and implement quality control workflows to ensure genetic integrity, reproducibility, and functional validation of engineered cell lines
Train and mentor graduate students, postdoctoral fellows, and technical staff in CRISPR genome editing methodologies and best practices
Serve as a technical and intellectual lead for complex genome engineering projects that support multiple ongoing research initiatives in the laboratory
Developing high-throughput screening methods to investigate the regulation of glycosylation in mammalian cell lines
Independently develop, optimize, and implement high-throughput, cell-based screening assays to interrogate glycosylation pathways and regulatory mechanisms
Design experimental pipelines integrating genome editing, phenotypic screening, and downstream biochemical and molecular analyses
Assay development, including optimization of reagents, detection methods, controls, and statistical rigor to ensure robust, reproducible datasets
Analyze and interpret genomic screening data and provide scientific direction on follow-up experiments and prioritization of targets
Supervise and coordinate screening-related efforts involving students and collaborators, ensuring proper training, execution, and documentation
Contribute intellectual leadership in experimental design and strategy development for grant-supported research projects
Prepare written and oral communication of research output
Ordering chemicals and consumables for the experiments as needed
Lab related activities, including meetings and collaborative projects
Lead preparation of figures, written summaries, and experimental documentation for manuscripts, grant applications, and progress reports
Present research findings in lab meetings, collaborative meetings, and internal and external scientific forums
Coordinate ordering, inventory management, and procurement of specialized reagents and consumables critical to advanced genome engineering and screening workflows
Participate in and help lead lab meetings, project planning discussions, and collaborative research initiatives
Provide mentorship and day-to-day scientific guidance to trainees, assisting with experimental troubleshooting, project development, and professional development
Qualification
Required
Master's degree in a related field of science and 5 years of professional experience
Preferred
PhD in biochemistry, genetics, cell biology or a related discipline
Benefits
Retirement Plan TRS or ORP
Benefits Eligible
Company
The University of Georgia
The University of Georgia, a land-grant and sea-grant university with state-wide commitments and responsibilities, is the state's flagship institution of higher education.
10001+ employees
Funding
Current Stage
Late StageLeadership Team
Mark Johnson
Chief Technology Officer, Grady College of Journalism and Mass Communication
Alan Dorsey
Professor of Physics and Associate Chief Information Officer for Research
Recent News
Alfred P. Sloan Foundation
2023-10-27
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