Personalis, Inc. · 8 hours ago
Sr. Network and Infrastructure Engineer
Fremont, CA
Full-time
Onsite
Senior Level
$150K/yr - $170K/yr
5+ years expPersonalis is transforming the active management of cancer through breakthrough personalized testing. We are seeking a highly skilled and versatile Senior Network & Infrastructure Engineer to lead the architecture and maintenance of our Cisco Nexus fabric and manage a modern hyperconverged infrastructure stack.
BiotechnologyGeneticsHealth CareHealth Diagnostics
Responsibilities
Network & Security Architecture (60%)
HPC Networking: Architect, deploy, and optimize Cisco Nexus switches within a High-Performance Computing (HPC) environment, ensuring low latency and high throughput
Security & Firewalls: Full lifecycle management of Cisco NextGen Firewalls (NGFW). You must be proficient in configuring security policies, routing, and VLAN segmentation
VPN Management: Lead the setup and maintenance of VPN connections (Site-to-Site and Remote Access) on Cisco platforms
Circuit Operations: Oversee the provisioning, monitoring, and troubleshooting of network circuits and ISP handoffs
Cloud Connectivity: Act as a subject matter expert for hybrid-cloud networking, supporting connectivity between on-premise hardware and AWS/GCP (Direct Connect/Cloud Interconnect)
Infrastructure & Systems Management (30%)
Virtualization: Administer and scale VMware clusters running on Dell VxRail hyperconverged infrastructure
HPC Storage: Support high-performance storage environments, specifically VAST Data and Dell Isilon, ensuring data availability for intensive workloads
Systems Administration: Provide tier-3 support for Linux (RHEL/Ubuntu/CentOS) and Active Directory environments
Enterprise Tech: Manage Cisco Meraki wireless and edge networking for corporate office connectivity
Data Protection: Ensure the integrity of the environment through rigorous backup schedules and disaster recovery testing
Physical Operations (10%)
Data Center Ops: Perform hardware installations (Rack & Stack), cable management, and physical troubleshooting in Colocation (Colo) and Data Center environments
Qualification
Required
5–8+ years of hands-on experience in network engineering and infrastructure
Advanced knowledge of Cisco Nexus (NX-OS) and Cisco NextGen Firewalls
Deep understanding of BGP, OSPF, VLANs, LACP, and VPN protocols (IPsec/SSL), WAN technologies
Proven experience with Dell server hardware and VxRail
Exposure to high-performance file systems (VAST, Isilon)
Ability to work on-site at data centers and office/labs, including lifting up to 50 lbs and working within server racks
Preferred
Experience with AWS (VPC, Transit Gateway) or GCP (Cloud Router)
CCNP (Data Center/Security), VCP (VMware Certified Professional), or AWS Solutions Architect
Prior experience working in R&D, scientific, or lab environments
Experience with Python, Ansible, or Terraform for infrastructure-as-code
Benefits
Medical
Dental
Vision
401(k) match
ESPP
Tuition reimbursement
Sick/vacation time
Commuter benefits/ EV charging stations
Onsite gym
Wellness benefits
Company
Personalis, Inc.
At Personalis, we are transforming the active management of cancer through breakthrough personalized testing.
201-500 employees
H1B Sponsorship
Personalis, Inc. has a track record of offering H1B sponsorships. Please note that this does not
guarantee sponsorship for this specific role. Below presents additional info for your
reference. (Data Powered by US Department of Labor)
Distribution of Different Job Fields Receiving Sponsorship
Represents job field similar to this job
Trends of Total Sponsorships
2025 (6)
2024 (10)
2023 (17)
2022 (19)
2021 (12)
2020 (7)
Funding
Current Stage
Public CompanyTotal Funding
$311.25MKey Investors
MerckTempusLightspeed Venture Partners
2024-12-19Post Ipo Equity· $50M
2024-08-16Post Ipo Equity· $36.15M
2021-01-27Post Ipo Equity· $150.1M
Leadership Team
Aaron Tachibana
Chief Financial Officer
Christian Haudenschild
Senior Vice President
Recent News
2026-01-09
Company data provided by crunchbase