Illumina · 7 hours ago
Enterprise Architect – SAP S/4HANA & Digital Enterprise Platforms
San Diego, CA
Full-time
Hybrid
Senior Level, Lead/Staff
$171K/yr - $256K/yr
15+ years expIllumina is a company dedicated to expanding access to genomic technology to enhance health equity globally. The Enterprise Architect will provide strategic architectural leadership for digital transformation initiatives, focusing on SAP S/4HANA and ensuring alignment between business strategy and technology platforms.
BiotechnologyGeneticsHealth CareMedical
Responsibilities
Own and evolve enterprise architecture vision, principles, standards, and roadmaps across business, application, data, and technology domains
Develop future-state architecture and associated transition roadmaps aligned with business growth objectives
Serve as a trusted advisor to business and IT leadership on architectural trade-offs, sequencing, and investment decisions
Lead and participate in architecture governance forums (Design Authority, Architecture Review Boards)
Define and govern SAP S/4HANA target-state architecture as the enterprise ERP backbone
Enforce clean-core principles, extensibility strategies (in-app vs side-by-side), and SAP best practices
Provide architectural guidance across SAP domains including Finance, Sales, Supply Chain, Manufacturing, Quality, EAM, and EHS
Build and maintain the ERP strategy and roadmap, including ECC-to-S/4 or multi-ERP coexistence scenarios
Provide architectural oversight and integration strategy for enterprise platforms, including but not limited to:
Ensure clear system-of-record ownership
Ensure scalable and resilient integration patterns
Ensure data consistency, reconciliation, and error-handling strategies
Define enterprise integration strategy (API-led, event-driven, middleware-based)
Govern integration platforms such as SAP BTP, CPI, MuleSoft, or equivalent
Lead ERP-related integration rationalization and optimization
Define master data ownership, governance models, and reporting strategies (real-time vs operational)
Ensure alignment with analytics, AI/ML, and data platform needs (e.g., data lakes)
Partner with PMO, delivery leads, and system integrators across Design, Build, Test, and Deploy
Review and approve solution artifacts (HLDs, FSDs, TSDs, integration and security designs)
Establish and promote business capability models linking strategy, processes, systems, and data
Identify architectural risks early and recommend mitigation strategies
Ensure adherence to quality standards across solution design and delivery
Ensure solutions meet security, SOX, GxP, data privacy, and regulatory requirements
Define and govern non-functional requirements: performance, scalability, availability, and disaster recovery
Guide system retirement, data retention, and audit readiness strategies
Build strong, trust-based relationships with business, functional, infrastructure, procurement, and IT teams
Provide architectural direction to system integrators and SaaS vendors
Evaluate and challenge vendor proposals and RFP responses to ensure alignment with enterprise standards
Research and assess emerging technologies for fit within the enterprise application portfolio
Qualification
Required
15+ years of experience in enterprise IT architecture and solution delivery
Proven experience leading large-scale digital and ERP transformation programs
Deep hands-on and architectural experience with SAP S/4HANA in enterprise environments
Typically requires a minimum of 18 years of related experience with a Bachelor's degree in Computer Science, Engineering, or related field; or 15 years and a Master's degree; or a PhD with 12 years experience; or equivalent experience
SAP S/4HANA architecture, extensibility, and integration
Enterprise integration patterns (API, middleware, event-driven)
Strong expertise in TOGAF, Zachman, or equivalent EA frameworks
Hands-on experience with business capability modeling
Ability to translate business strategy into executable architecture
Excellent communication, influence, and consensus-building skills
Strong analytical and problem-solving capabilities
Preferred
Experience in Life Sciences, Manufacturing, or regulated industries
SAP certifications (S/4HANA, Architecture, BTP)
Experience with digital manufacturing, advanced analytics, or AI-enabled platforms
Prior experience with ERP modernization or multi-year transformation programs
Benefits
Access to genomics sequencing
Family planning
Health/dental/vision
Retirement benefits
Paid time off
Company
Illumina
Illumina is an innovative technology and revolutionary assays aiming the analyze genetic variation and function.
5001-10000 employees
H1B Sponsorship
Illumina has a track record of offering H1B sponsorships. Please note that this does not
guarantee sponsorship for this specific role. Below presents additional info for your
reference. (Data Powered by US Department of Labor)
Distribution of Different Job Fields Receiving Sponsorship
Represents job field similar to this job
Trends of Total Sponsorships
2025 (134)
2024 (116)
2023 (159)
2022 (180)
2021 (123)
2020 (111)
Funding
Current Stage
Public CompanyTotal Funding
$1.28BKey Investors
Bank of America
2024-09-06Post Ipo Debt· $500M
2023-01-04Post Ipo Debt· $750M
2000-07-28IPO
Leadership Team
Steven Barnard
Chief Technology Officer, Head of Research & Product Development
Jenny Lei Zheng
SVP & GM of Greater China
Recent News
2026-02-03
Company data provided by crunchbase