Flagship Pioneering · 21 hours ago
Senior Scientist II/Principal Scientist, Protein Sciences
Cambridge, MA
Full-time
Onsite
Senior Level, Lead/Staff
$143K/yr - $214K/yr
8+ years expFlagship Pioneering is a bioplatform innovation company that invents and builds companies that change the world. The individual in this role will serve as a technical leader and foundational builder of the Protein Sciences team, owning the strategy, design, and execution of protein construct development and production across multiple expression systems and scales.
FinanceFinancial ServicesVenture Capital
Responsibilities
Lead the design, development, and implementation of protein expression and production strategies, determining the feasibility and optimal application of scientific approaches across targets
Own protein production workflows across multiple hosts and scales (e.g., coli, B. subtilis, Pichia pastoris, cell-free systems; deep-well plates and shake flasks), ensuring rigor, reproducibility, and alignment with scientific and company objectives
Provide high-level technical expertise in protein quantification and validation, establishing fit-for-purpose analytical strategies (e.g., HiBit, Western analysis, related methods) to support decision-making
Manage and direct external CRO relationships, including protocol development, tech transfer, timelines, and budget considerations, while ensuring quality and strategic alignment
Contribute to the development of the Protein Sciences team by establishing best practices, documentation standards, and collaboration; support strategic planning and, with team growth, mentor or manage additional scientists
Qualification
Required
PhD (or equivalent industry experience) in protein science, biochemistry, molecular biology, bioengineering, or a related discipline, with 8-12 years (at least 5 in industry) of deep hands-on experience in protein expression and production
Demonstrated ownership of protein construct design and production across multiple expression systems and scales, including microbial and/or cell-free platforms, with a track record of delivering reproducible, decision-enabling data
Experience determining the feasibility and application of advanced protein science approaches to support scientific programs, including selecting hosts, formats, and analytical strategies aligned with program objectives
Proven ability to lead complex technical work with minimal oversight, including managing external CRO relationships, protocol development or transfer, timelines, and resource considerations (e.g., budgets, trade-offs)
Experience operating as a technical leader-either through mentoring scientists, guiding cross-functional collaborators, establishing best practices, or contributing to strategic scientific planning in an industry setting
Benefits
Healthcare coverage
Annual incentive program
Retirement benefits
Broad range of other benefits
Company
Flagship Pioneering
Flagship Pioneering is a venture capital firm that invests in life sciences and healthcare companies.
501-1000 employees
H1B Sponsorship
Flagship Pioneering has a track record of offering H1B sponsorships. Please note that this does not
guarantee sponsorship for this specific role. Below presents additional info for your
reference. (Data Powered by US Department of Labor)
Distribution of Different Job Fields Receiving Sponsorship
Represents job field similar to this job
Trends of Total Sponsorships
2025 (8)
2024 (4)
2023 (4)
2022 (4)
2021 (1)
Funding
Current Stage
Late StageLeadership Team
Noubar Afeyan
Founder and CEO
Chuck Carelli
Chief Financial Officer
Recent News
2026-02-06
Genetic Engineering News
2026-02-05
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2026-02-05
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