Flagship Pioneering · 1 day ago
Principal Scientist, Women's Health & Preeclampsia
Boston, MA
Full-time
Hybrid
Senior Level, Lead/Staff
$163K/yr - $214K/yr
7+ years expFlagship Pioneering is a biotechnology company focused on discovering novel proteins to develop transformative medicines. They are seeking a Principal Scientist to lead discovery efforts in Women’s Health, particularly in preeclampsia and hypertensive disorders of pregnancy, providing scientific leadership and collaborating with various teams to advance therapeutic targets.
FinanceFinancial ServicesVenture Capital
Responsibilities
Provide scientific leadership for discovery research in preeclampsia and hypertension in pregnancy by designing, executing, and interpreting mechanistic studies using state-of-the-art experimental models and technologies
Lead target validation efforts informed by proteomic and computational insights; develop hypotheses, assess risk, and prioritize targets with strong translational potential
Partner closely with computational biology and proteomics teams to apply AI-enabled approaches to large-scale datasets (e.g., proteomic, transcriptomic, genetic) and generate novel biological insights
Design and oversee in vitro and in vivo disease models to support target biology, biomarker development, and proof-of-concept studies
Contribute meaningfully to building and refining the company’s therapeutic strategy in Women’s Health, including scientific decision-making and portfolio discussions
Communicate scientific findings clearly and effectively in cross-functional forums, external collaborations, and presentations to senior leadership
Support or lead external academic and industry collaborations, including scientific strategy, execution oversight, and data integration
Operate in a hybrid role, with approximately 75% focus on scientific leadership, strategy, and collaboration, and 25% hands-on laboratory work, as appropriate
Qualification
Required
Ph.D. in Physiology, Cell Biology, or a related discipline; postdoctoral training and/or industry experience strongly preferred
7+ years of relevant postdoctoral and/or industry experience, consistent with Senior Principal Scientist-level impact and scope
Deep understanding of disease mechanisms and translational models in one or more of the following areas: preeclampsia, hypertension, placental development and function, or related biology
Hands-on expertise in cellular and molecular biology techniques (e.g., CRISPR, ELISA, qPCR, Western blotting, RNA-seq) and assay development
Experience with in vitro and/or in vivo models relevant to the study of pregnancy and related disorders
Demonstrated ability to integrate multi-omic and/or genetic data into experimental design and biological interpretation
Strong track record of scientific contributions, including publications, patents, and/or scientific presentations
Excellent communication, collaboration, and organizational skills, with the ability to operate effectively in a fast-paced, team-oriented environment
Preferred
Experience working in early-stage biotech or drug discovery environments
Familiarity with target identification and validation workflows
Experience working with human tissue samples, iPSC-derived systems, and/or organoid models
Benefits
Healthcare coverage
Annual incentive program
Retirement benefits
Broad range of other benefits
Company
Flagship Pioneering
Flagship Pioneering is a venture capital firm that invests in life sciences and healthcare companies.
501-1000 employees
H1B Sponsorship
Flagship Pioneering has a track record of offering H1B sponsorships. Please note that this does not
guarantee sponsorship for this specific role. Below presents additional info for your
reference. (Data Powered by US Department of Labor)
Distribution of Different Job Fields Receiving Sponsorship
Represents job field similar to this job
Trends of Total Sponsorships
2025 (8)
2024 (4)
2023 (4)
2022 (4)
2021 (1)
Funding
Current Stage
Late StageLeadership Team
Noubar Afeyan
Founder and CEO
Chuck Carelli
Chief Financial Officer
Recent News
2026-02-06
Genetic Engineering News
2026-02-05
Bizjournals.com Feed (2025-11-12 15:43:17)
2026-02-05
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