Ionis Pharmaceuticals, Inc. · 17 hours ago
Temporary Research Associate / Scientist
Carlsbad, California, United States
Full-time
Hybrid
Entry, Mid Level
$37.07/hr - $49.03/hr
2+ years expIonis Pharmaceuticals, Inc. is a leader in RNA-targeted medicines, dedicated to transforming lives through innovative drug discovery. They are seeking a highly motivated research associate or scientist to join their medicinal chemistry team, focusing on the development and optimization of oligonucleotide conjugates for targeted delivery of nucleic acid therapeutics.
BiotechnologyHealth CareMedicalPharmaceutical
Responsibilities
Synthesis of chemically modified oligonucleotides on oligonucleotide synthesizers
Design, execute and optimize bioconjugation strategies for linking ASOs, siRNAs, or other oligonucleotides to antibodies, peptides and other ligands with a variety of bioconjugation chemistries
Purification of oligonucleotides conjugates utilizing common HPLC methodologies
Characterize conjugates using a variety of analytical techniques, including chromatography, and mass spectrometry
Collaborate cross-functionally with colleagues in medicinal chemistry, cell biology, and drug discovery to advance project objectives related to targeted delivery
Data analysis, troubleshooting, and contributing to project planning and strategy discussions
Qualification
Required
Bachelor's or Master's degree in Biochemistry, Chemistry, or related field with 2+ years of laboratory experience in bioconjugation
Experience in nucleoside/oligonucleotide synthesis and purification
Experience with purification techniques (e.g., ion exchange, reverse-phase, and size-exclusion chromatography)
Proficiency with and mechanistic understanding of common bioconjugation chemistries including SPAAC and Maleimide
Proficiency in common analytical techniques including HPLC and mass spectrometry
Ability to work independently, prioritize tasks, and adapt to changing project needs in a fast-paced research environment
Excellent communication skills and a collaborative mindset, with the ability to effectively interact with multidisciplinary teams
Preferred
Experience with oligonucleotide chemistry
Company
Ionis Pharmaceuticals, Inc.
For three decades, Ionis has invented medicines that bring better futures to people with serious diseases.
501-1000 employees
H1B Sponsorship
Ionis Pharmaceuticals, Inc. has a track record of offering H1B sponsorships. Please note that this does not
guarantee sponsorship for this specific role. Below presents additional info for your
reference. (Data Powered by US Department of Labor)
Distribution of Different Job Fields Receiving Sponsorship
Represents job field similar to this job
Trends of Total Sponsorships
2025 (8)
2024 (5)
2023 (3)
2022 (5)
2021 (5)
2020 (1)
Funding
Current Stage
Public CompanyTotal Funding
$2.45B2025-11-13Post Ipo Debt· $700M
2024-09-09Post Ipo Equity· $500.3M
2023-06-06Post Ipo Debt· $500M
Leadership Team
Brett P. Monia
Chief Executive Officer
Eric Bastings
Senior Vice President, Development Strategy
Recent News
Labiotech UG
2026-01-22
Business Wire
2026-01-22
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