MUSC Health · 1 day ago
UNIV - Staff Scientist I - Department of Neurosciences
Charleston, SC
Full-time
Onsite
Senior Level, Lead/Staff
2+ years expMUSC Health is seeking a talented and motivated staff scientist to join the C. Schmidt lab at the Department of Neurosciences. The role involves leading research in pediatric brain cancer and early brain development, utilizing various molecular and stem cell biology techniques.
Health CareHospitalMedical
Responsibilities
Lead and train laboratory staff in tissue culture work
Maintain and use stem cell lines and primary cell cultures for experimental purposes, this includes and is not limited to human iPS cells, neuronal stem cell cultures, human tumor cell lines, standard fibroblast cultures (HEK 293T) and brain organoid cultures
Experimental tissue culture work includes, proliferation or cell/death assays, drug treatments, transfections, lentivirus production and viral transductions (BSL2 work)
It is also the responsibility of the staff scientist to maintain a clean environment in the tissue culture room, upkeep inventory including reagent stocks and aliquots, and oversea equipment maintenance in teamwork with any other lab managers/research specialists in the Schmidt lab
Lead laboratory staff in molecular biology techniques, particularly cloning targeting constructs and CRISPR/Cas9, RNA and protein isolation, qRT-PCR, western blot, immunofluorescence and immunohistochemistry staining and microscopy, cryosectioning of cryo-frozen tissue blocks, flow cytometry, handling plasmids and bacteria, preparing lab reagents, analyzing data for scientific reports
Maintain laboratory supplies and consumables, perform routine cleaning of laboratory and tissue culture space, clean glassware and autoclave glassware and plastics, ensure safety and compliance guidelines, introduce new lab members to the lab space and work
Assist the principal investigator in establishing an efficient lab, foster science and training
Carry out dissections of tissue from mouse cadavers, processing of tissue and dissociated cells for further analysis and downstream assays
Prepare initial versions of manuscripts, abstracts, progress reports and SOPs that include publication-quality figures, detailed experimental methods and drafts of the introduction, results and discussion sections
Prepare posters for presentations at national and international meetings
Qualification
Required
PhD, MD or equivalent
Minimum 2 years research experience post-doctorate
Modest publication record
Strong organizational, multitasking, and communication skills
Ability to work independently and as a member of a research team
Can Manage projects of moderate size with PI input
Experience with culturing mammalian cells
Experience with molecular biology and biochemistry techniques, such as molecular cloning, qRT-PCR, shRNA/siRNA gene knockdown, immunoblotting/immunofluorescence imaging
Ability to obtain and maintain a valid drivers license
Computer literacy
Ability to work rotating shifts as required
Ability to work overtime as required
Ability to learn and use new processes, tools and equipment as required
Preferred
Experience in a few molecular and stem cell biology techniques, including genetic editing via lentiviral infection or CRISPR/Cas9 systems, RNA/ATAC/CUT&RUN sequencing, human induced-pluripotent stem cell and human neural stem cell cultures, human brain organoid cultures and mouse intracranial injections
Enthusiasm for research and learning new skills
Company
MUSC Health
MUSC Health provides health-care services through its patient- and family-centered care, education, research, and various partnerships. It is a sub-organization of Medical University of South Carolina.
Founded in 1824Charleston, South Carolina, USA
10001+ employees
Funding
Current Stage
Late StageTotal Funding
$133MKey Investors
Armadale Capital
2019-12-19Debt Financing· $133M
Leadership Team
Erik Summers
Chief Medical Officer
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