Merck · 11 hours ago
Associate Principal Scientist, Antibody Discovery Innovation
USA - California - South San Francisco (Grand Ave)
Full-time
Hybrid
Senior Level, Lead/Staff
$160K/yr - $251K/yr
4+ years expMerck is committed to being the world’s premier, most research-intensive biopharmaceutical company. They are seeking an exceptional and experienced scientist for the role of Associate Principal Scientist in the South San Francisco Discovery Biologics group, focusing on improving antibody discovery processes and managing antibody discovery programs.
BiotechnologyHealth CareMedicalPharmaceutical
Responsibilities
Propose and lead technology development initiatives for in vivo de novo antibody discovery to increase hits and decrease timelines
Serve as the antibody discovery representative on project teams to help define Target Candidate Profiles (TCP) and lead de novo hit finding strategies and campaigns
Stay abreast of external advancements in relevant scientific and technology fields
Promote the external reputation of our company’s Discovery Biologics department
Qualification
Required
Master's (with 8+ years) or Ph.D. (with 4+ years) in biophysics, biochemistry, structural biology or related science discipline and relevant industry experience
Experience in antibody drug discovery supporting therapeutic programs
Depth of knowledge in adaptive immunity and B-cell biology
Track record of driving scientific and platform innovations
Experience leading therapeutic antibody discovery campaigns
Strong hands-on laboratory skills, including but not limited to cell culture, molecular biology, assay development, and flow cytometry
Established external reputation through publications, presentations, and/or scientific community engagement
Excellent communication and collaboration skills
Ability to manage multiple projects simultaneously
Preferred
Ideal candidate will have experience in protein therapeutics beyond traditional mAbs including alternative non-Ig scaffolds, bi- or multi-specifics, fusion proteins, and ADCs
Benefits
Medical
Dental
Vision healthcare and other insurance benefits (for employee and family)
Retirement benefits, including 401(k)
Paid holidays
Vacation
Compassionate and sick days
Company
Merck
Merck is a biopharmaceutical company that offers medicines and vaccines for various diseases.
10001+ employees
Funding
Current Stage
Public CompanyTotal Funding
$5.59MKey Investors
Private Capital Advisors"Gavi, the Vaccine Alliance"
2018-11-25Post Ipo Equity· $0.59M
2016-01-21Series Unknown· $5M
1980-12-19IPO
Leadership Team
Betty Larson
Executive Vice President and Chief Human Resources Officer
Dean Li
Executive Vice President and President, Merck Research Laboratories
Recent News
2026-02-05
Genetic Engineering News
2026-02-05
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