Sarepta Therapeutics · 4 days ago
Scientist II, RNA Process Development
Bedford, MA
Full-time
Onsite
Mid, Senior Level
$112K/yr - $140K/yr
3+ years expSarepta Therapeutics is at the forefront of genetic medicine, focusing on therapies for Duchenne muscular dystrophy and other diseases. The Scientist II, RNA Process Development will contribute to the development and characterization of RNA drug substances, focusing on synthetic route design and impurity identification.
BiotechnologyHealthcareLife ScienceGeneticsHealth CareTherapeutics
No H1B
Responsibilities
Design and execute synthetic routes for novel small molecules, intermediates, degradation products, and impurities related to RNA drug substance manufacturing
Develop scalable, robust synthetic procedures; evaluate reaction scope, optimization, and critical process parameters
Identify, elucidate, and synthesize process‑related impurities and degradants using spectroscopic data (NMR, LC‑MS, HRMS, IR)
Collect, review, and present process data in group settings and apply statistical methodology to evaluate and optimize process operations
Support scale‑up efforts from milligram to multi‑gram quantities; contribute to tech transfer to internal pilot‑scale labs or external CRO/CMO partners
Evaluate reaction safety, solvent selection, impurity formation mechanisms, and scalability risks
Engage in troubleshooting sessions for processes and products manufactured in-house and at CMOs
Perform technical review of executed Batch Production Records from CMOs during Technology Transfer
Serve as a subject matter expert in cross-functional teams, influencing decisions on CMC strategy, regulatory filings, and risk mitigation
Consistently demonstrate an ability to manage a diverse workload to lead and complete assignments according to project schedules and timelines
Author and review regulatory and technical documents
Other duties as assigned
Qualification
Required
Advanced degree in Organic Chemistry or related field with 3 – 5 years of experience
Proven track record of leading complex process development projects and influencing technical strategy
Expertise in organic synthesis, flash chromatography, solid-phase synthesis, bioconjugation
Strong knowledge of standard oligonucleotide and organic analytical techniques (HPLC, LC-MS, NMR, TLC, GC-MS, IR, etc.)
Demonstrated ability to operate independently, exercise judgment in ambiguous situations, and make strategic decisions
Exceptional communication skills for influencing leadership and external stakeholders
Commitment to Sarepta's cultural values
Exercises judgment within broadly defined practices and policies in selecting methods, techniques and evaluation criteria for obtaining results
Demonstrates effective written and verbal communication skills
Able to handle multi-task workload and perform duties in a fast-paced environment
Preferred
Knowledge with oligonucleotide‑related building blocks or phosphoramidite chemistry (preferred but not required)
Familiarity with reaction scale‑up fundamentals and lab‑to‑pilot transfer considerations
Understanding of QbD principles, DoE methodology, and statistical modeling tools (JMP, Matlab) are a plus
Benefits
Physical and Emotional Wellness
Financial Wellness
Support for Caregivers
Competitive compensation and benefit package
Company
Sarepta Therapeutics
Sarepta Therapeutics focuses on the discovery and development of precision genetic medicine to treat rare diseases.
501-1000 employees
Funding
Current Stage
Public CompanyTotal Funding
$2.88BKey Investors
Michael Andrew ChambersPharmakon AdvisorsMidCap Financial
2025-12-11Post Ipo Debt· $291.4M
2025-08-21Post Ipo Equity
2025-08-21Post Ipo Debt· $602M
Leadership Team
Ian Estepan
Executive Vice President, Chief Financial Officer
K
Kathy Behrens Wilsey
Director
Recent News
2026-02-06
2026-02-05
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