10x Genomics · 8 hours ago
Staff Mechanical Engineer, Consumables
Pleasanton, California, USA HQ
Full-time
Onsite
Lead/Staff
$179K/yr - $242K/yr
10+ years exp10x Genomics is committed to accelerating our understanding of biology through innovative technologies. As a Staff Mechanical Engineer, you will lead the design and development of complex biotech consumables, ensuring regulatory compliance and product scalability while mentoring junior engineers and collaborating across functions.
Biotechnology
Responsibilities
Lead the architecture and design of complex biotech consumables, focusing on Injection Molded (IM) plastics, over-molding, LSR and assembly techniques (ultrasonic welding, laser bonding)
Drive the development of fluidic and microfluidic systems by consulting with fluidic SMEs, ensuring seamless integration between consumable cartridges and permanent instrument hardware
Utilize FEA, tolerance analysis, and CFD to predict part behavior and ensure robust performance under laboratory operating conditions
Design for compliance with ISO 13485, FDA 21 CFR Part 820 as well as RUO. Contribute to the creation of Design History Files (DHF)
Take full ownership of critical subsystems from "napkin sketch" through high-volume manufacturing (HVM)
Champion Design for Manufacturing (DFM) and Design for Assembly (DFA), working closely with toolmakers and CMOs to ensure tool designs and strategies are optimized
Act as the primary technical point of contact for external molding partners and material suppliers, ensuring quality and performance standards are met
Identify and pursue patentable innovations in fluid handling, sealing technologies, and consumable-to-instrument interfaces
Lead complex failure analysis (FEA, SEM, etc.) for plastic components, identifying issues like creep, stress cracking, or biocompatibility failures and implementing permanent corrective actions
Directly mentor junior Engineers, fostering a culture of rigorous engineering discipline and creative problem-solving
Serve as the "mechanical voice" in rooms full of Biologists, Chemists, and Software Engineers to ensure the hardware meets the underlying science
Qualification
Required
BS/MS in Mechanical Engineering
10+ years of experience in mechanical design, with at least 5 years specifically in medical devices or biotech consumables
Deep knowledge of thermoplastic resins (COC, COP, PC, PP), elastomers (TPE/TPU), and the nuances of high-volume injection molding
Experience with CAD (SolidWorks/Creo), PDM systems, and simulation suites
Familiarity with Risk Management (ISO 14971), FMEA, and Gage R&R
Benefits
10x’s equity grants
Comprehensive health and retirement benefit programs
Annual bonus program or sales incentive program
Company
10x Genomics
Cells are the basic unit of life.
1001-5000 employees
H1B Sponsorship
10x Genomics has a track record of offering H1B sponsorships. Please note that this does not
guarantee sponsorship for this specific role. Below presents additional info for your
reference. (Data Powered by US Department of Labor)
Distribution of Different Job Fields Receiving Sponsorship
Represents job field similar to this job
Trends of Total Sponsorships
2025 (41)
2024 (40)
2023 (35)
2022 (52)
2021 (34)
2020 (16)
Funding
Current Stage
Late StageLeadership Team
Serge Saxonov
Co-founder and CEO
Eric Whitaker
Executive Vice President and Chief Legal Officer
Recent News
2024-05-07
2024-04-30
2024-04-08
Company data provided by crunchbase