Sanofi · 1 day ago
Principal Scientist Formulation
Cambridge, MA
Full-time
Onsite
Senior Level, Lead/Staff
5+ years expSanofi is an R&D-driven, AI-powered biopharma company committed to improving people’s lives. The Principal Scientist Formulation will play a key role in the development of oral solid dosage formulations for small molecule drug products, responsible for designing, developing, and optimizing preclinical formulations and clinical solid oral dosage forms.
BiotechnologyHealthcarePharmaceuticalLife ScienceHealth CareTherapeutics
Responsibilities
Design and develop oral solid dosage formulations (tablets, capsules, granules) to support preclinical and clinical programs
Execute formulation studies including excipient compatibility, prototype development, and formulation optimization
Develop both conventional and enabling formulations (e.g., amorphous dispersions) as needed to address bioavailability challenges
Lead formulation and process development activities, including granulation (wet and dry), blending, compression/tableting, and encapsulation
Apply DoE methodologies to optimize formulation and process parameters
Scale up formulations from laboratory to pilot and production scale
Troubleshoot manufacturing issues and implement solutions
Execute technology transfers of developed formulations from R&D to GMP manufacturing sites
Collaborate within the CMC team as a contributing member, supporting defined deliverables and milestones
Work with Analytical, Biopharm, Toxicology, Quantitative Pharmacolog, DMPK, Quality, and Regulatory colleagues to ensure alignment on development strategies
Partner with Research teams to evaluate molecular attributes relevant to drug delivery and formulation design
Author and review technical reports, batch records, and regulatory documents
Ensure all documentation is accurate, complete, and compliant with GMP requirements
Maintain awareness of current scientific literature and apply new concepts as appropriate
Qualification
Required
PhD in a scientific field with 5+ years of relevant experience within the pharmaceutical/biotech industry or a Master's degree with a minimum of 8 years experience
Hands-on experience with preclinical formulation development especially amorphous solid dispersion, lipid based and nanosuspension formulations
Strong knowledge of CMC pharmaceutical development, including hands-on operation of manufacturing equipment and laboratory instruments (compression, wet/dry granulation, capsule filling, coating, etc.)
Experience with process development, optimization, and scale-up activities of solid oral dosage forms for clinical development phases
Familiarity with technology transfer processes and working with CROs/CMOs
Working knowledge of scientific and statistical approaches including DoE and data analysis
Excellent laboratory skills and the desire to conduct lab work
Demonstrated hands-on experience with oral solid dosage manufacturing equipment, including: Amorphous solid dispersion, nanosuspension and lipid based formulations, Tablet presses (rotary and single-station compression), Granulation equipment (high-shear, fluid bed, roller compaction), Capsule filling machines, Coating equipment, Compaction Simulators
Strong understanding of powder characterization techniques and their application to formulation development
Strong problem-solving skills and scientific curiosity
Effective oral and written communication skills
Ability to work collaboratively in a team environment
Good organizational skills with ability to manage multiple projects
Experience with outsourcing and overseeing work done by CRO/CMOs
Experience working with cross-functional teams
Excellent communication skills
Track record of scientific publications
Preferred
A degree in Pharmaceutics
Benefits
High-quality healthcare
Prevention and wellness programs
At least 14 weeks’ gender-neutral parental leave
Company
Sanofi
Sanofi is a global biopharma company focused on prescription drugs, vaccines, and treatments for chronic, rare, and infectious diseases.
10001+ employees
H1B Sponsorship
Sanofi has a track record of offering H1B sponsorships. Please note that this does not
guarantee sponsorship for this specific role. Below presents additional info for your
reference. (Data Powered by US Department of Labor)
Distribution of Different Job Fields Receiving Sponsorship
Represents job field similar to this job
Trends of Total Sponsorships
2025 (101)
2024 (68)
2023 (59)
2022 (78)
2021 (38)
2020 (38)
Funding
Current Stage
Public CompanyTotal Funding
$6.98BKey Investors
Blackstone Life SciencesEvotec
2025-10-28Post Ipo Debt· $3B
2025-06-17Post Ipo Debt· $1.72B
2025-03-05Post Ipo Debt· $1.62B
Leadership Team
Paul Hudson
Chief Executive Officer
Francois-Xavier Roger
Chief Financial Officer
Recent News
2026-02-09
2026-02-09
Company data provided by crunchbase