Pfizer · 11 hours ago
Principal Scientist-Process Development
United States - Connecticut - Groton
Full-time
Onsite
Senior Level, Lead/Staff
$106K/yr - $172K/yr
4+ years expPfizer is a leading pharmaceutical company, and they are seeking a highly motivated Peptide Chemist with expertise in enzymatic peptide synthesis and biocatalysis. The role involves designing innovative processes for peptide and API manufacturing, collaborating across R&D and manufacturing organizations, and contributing to scalable synthetic technologies.
BiotechnologyMedical DeviceHealthcarePharmaceuticalHealth CareMedicalPrecision Medicine
No H1B
Responsibilities
Independently design, develop, and optimize enzymatic platforms, protocols, and workflows for peptide bond formation and related transformations
Evaluate and integrate emerging technologies in peptide synthesis and biocatalysis to meet process chemistry and manufacturability targets
Conduct enzyme screening campaigns, reaction optimization, and scale‑up to support development through late‑stage research and process transfer
Independently plan and execute experiments with well‑defined objectives, robust controls, and quantitative data analysis
Maintain high‑quality experimental records in electronic notebooks in full compliance with internal and regulatory expectations
Participate in multidisciplinary brainstorming to propose new enzyme‑enabled and organic synthetic routes for peptide and API production
Stay current with advances in biocatalysis, peptide chemistry, enzymology, and synthetic methodology through active review of primary literature
Apply structure–function understanding of enzymes to guide engineering or selection of improved biocatalysts when needed
Partner closely with chemists, analytical scientists, biochemical engineers, and manufacturing colleagues across the R&D and global supply network
Contribute to the design of robust, scalable enzymatic processes suitable for technology transfer and implementation in manufacturing environments
Communicate results and recommendations through regular team interactions and project updates
When assigned, coach, mentor, train, and develop junior staff, including supervision of experimental planning and troubleshooting
Participate in hiring processes and onboarding of new team members
Prepare high‑quality research reports, internal presentations, and external scientific publications or conference presentations
Clearly communicate scientific findings and strategic insights to technical and non‑technical stakeholders
Qualification
Required
PhD in Organic Chemistry, Biochemistry, Chemical Biology, Biocatalysis, Enzymology, Biochemical Engineering, or a closely related discipline, with minimum of 4+ years of relevant experience
Demonstrated expertise in enzymatic reactions, biocatalysis and enzyme enabled peptide synthesis
Strong experimental skills, including reaction optimization, data interpretation, and troubleshooting
Experience with enzyme screening, reaction scale up, and process-oriented thinking
Preferred
Industry experience in pharmaceuticals, biotech, or chemical process development
Hands on experience with peptide synthesis (solution phase, solid phase, chemoenzymatic methods)
Familiarity with enzyme engineering tools or directed evolution approaches
Understanding of process chemistry constraints (e.g., green chemistry, robustness, scalability)
Strong communication, documentation, and interpersonal skills
Demonstrated ability to collaborate effectively across multidisciplinary teams
Benefits
Participation in Pfizer’s Global Performance Plan with a bonus target of 15.0% of the base salary
Eligibility to participate in our share based long term incentive program
401(k) plan with Pfizer Matching Contributions
Additional Pfizer Retirement Savings Contribution
Paid vacation
Holiday and personal days
Paid caregiver/parental and medical leave
Health benefits to include medical, prescription drug, dental and vision coverage
Company
Pfizer
Pfizer is a biopharmaceutical company that discovers, develops, and delivers medicines and vaccines.
10001+ employees
Funding
Current Stage
Public CompanyTotal Funding
$38BKey Investors
Starboard Value
2025-11-21Post Ipo Debt· $6B
2024-10-07Post Ipo Equity· $1B
2023-05-16Post Ipo Debt· $31B
Leadership Team
Albert Bourla
Chief Executive Officer
Ian Read
Chief Executive Officer
Recent News
2026-02-09
Company data provided by crunchbase