AbbVie · 22 hours ago
Senior Scientist II, Peptide Discovery
Worcester, MA
Full-time
Onsite
Mid, Senior Level
4+ years expAbbVie is a biopharmaceutical company focused on discovering and delivering innovative medicines. They are seeking a Senior Scientist II with expertise in immunology and peptide biology to lead research initiatives in peptide therapeutics, collaborating with cross-functional teams to advance immunology programs.
BiotechnologyFinanceHealthcarePharmaceuticalVenture CapitalFinancial ServicesHealth CareMedical
Responsibilities
Innovative assay development and optimization: Independently design and execute immunological assays (e.g., ligand-receptor interaction, multi-color flow cytometry, potency whole blood, PBMC & cell line assays, co-culture systems, ELISPOT, ELISA/MSD, ddPCR, RNA-seq, HTS, etc.) to evaluate peptide therapeutics, uncover mechanisms of action in immune pathways. Ensure assay robustness, sensitivity, and reproducibility across programs for reliable data-driven decision-making
PK/PD Relationship: Apply analytical techniques, including multi-color flow cytometry for detailed cell signaling and phenotype analysis and molecular assays (digital PCR, qPCR, RNA extraction and sequencing) to quantify biomarkers and gene expression changes to build a PK/PD relationship
Data analysis & interpretation: Analyze and interpret complex experimental datasets to derive meaningful insights on peptide candidate efficacy and mechanism of action and adjust research directions based on data trends and scientific rationale
Experimental execution & quality: Lead hands-on laboratory studies and complex cellular assays with exceptional attention to detail, generating high-quality, reproducible data while maintaining rigorous documentation and data integrity standards
Cross-functional collaboration: Work closely with cross-functional teams (e.g., DMPK, in vivo pharmacology, medicinal chemistry, and platform technology groups) to integrate pharmacokinetic, pharmacodynamic, and efficacy data, aligning experimental plans with overall program objectives and timelines
Scientific communication: Prepare and deliver clear, concise technical reports and presentations on research findings, and contribute to external scientific communications (conference presentations, peer-reviewed publications) to highlight the team’s peptide immunology advancements
IND-enabling support: Contribute to IND-enabling efforts by designing critical preclinical studies, compiling and QC-reviewing data for regulatory documents, and supporting the authoring of IND submission sections to facilitate smooth progression of peptide candidates into clinical trials
Mentorship & team support: Provide informal mentorship and technical guidance to junior scientists, assisting with experimental design and troubleshooting, and fostering a collaborative lab environment that emphasizes scientific rigor, data quality, and continuous learning
Innovation & continuous learning: Stay current with emerging immunology research and technological advances; proactively introduce new techniques, instrumentation, or analytical methods to improve assay capabilities and drive innovation in peptide program strategies
Project leadership & initiative: Take initiative in planning and executing project sub-aims or exploratory studies, coordinating resources effectively, solving technical challenges, and ensuring key milestones are met in alignment with program goals
Translational integration: Bridge in vitro findings with in vivo outcomes by coordinating closely with pharmacology teams on the design of animal studies and subsequent tissue analysis, thereby ensuring peptide candidates are evaluated comprehensively for immunological efficacy and mechanism of action
Qualification
Required
BS, MS, or PhD in Immunology or a related biological discipline, with typically 12+ (BS), 10+ (MS), or 4+ (PhD) years of relevant experience
Strong theoretical and practical foundation in pharmacology and immunology, including knowledge of inflammatory pathways, immune cell trafficking, and oral delivery kinetics
Hands-on proficiency with rodents and a range of immunological and molecular biology techniques, including rodents and human tissue processing and analysis, cellular uptake/internalization of receptors, complex cell-based assays, multi-color flow cytometry, ELISPOT, and digital PCR/qPCR
Experience contributing to IND-enabling studies or other regulated preclinical research efforts
Ability to analyze, interpret, and clearly communicate complex experimental data
Strong scientific writing and verbal communication skills, including preparing technical reports, delivering presentations, and engaging in cross-functional discussions
Demonstrated ability to work both independently and collaboratively in cross-functional teams
Informal mentorship skills, including training junior scientists and helping troubleshoot experiments
Excellent attention to detail, effective time management skills, adaptability, and a willingness to learn and implement new technologies
Benefits
Paid time off (vacation, holidays, sick)
Medical/dental/vision insurance
401(k)
Short-term incentive program
Long-term incentive program
Company
AbbVie
AbbVie is a biopharmaceutical company focused on immunology, oncology, neuroscience, virology, and aesthetics. It is a sub-organization of AbbVie.
10001+ employees
H1B Sponsorship
AbbVie has a track record of offering H1B sponsorships. Please note that this does not
guarantee sponsorship for this specific role. Below presents additional info for your
reference. (Data Powered by US Department of Labor)
Distribution of Different Job Fields Receiving Sponsorship
Represents job field similar to this job
Trends of Total Sponsorships
2025 (273)
2024 (190)
2023 (225)
2022 (284)
2021 (186)
2020 (186)
Funding
Current Stage
Public CompanyTotal Funding
$15B2024-02-27Post Ipo Debt· $15B
2023-03-08Post Ipo Equity· $0.25M
2012-12-20IPO
Leadership Team
Robert Michael
Chairman of the Board and Chief Executive Officer
Micah Bregman
Vice President, Global Strategy and Pipeline, Allergan Aesthetics
Recent News
2026-02-12
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2026-02-12
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