Nautilus Biotechnology · 15 hours ago
Senior Software Engineer II, Instrument Control
San Carlos, CA
Full-time
Onsite
Senior Level
$164K/yr - $221K/yr
7+ years expNautilus Biotechnology is on a mission to improve health through innovative protein analysis technology. They are seeking a Senior Software Engineer II to lead the development and support of firmware and software systems for their instrument, ensuring seamless integration and collaboration across various scientific disciplines.
BiotechnologyHealthcarePharmaceuticalLife ScienceHealth Care
Responsibilities
Make major contributions to system architecture and design improvements
Design and implement software to control and coordinate multiple hardware components to ensure robust, reliable and maintainable Nautilus instruments
Work closely and cross-functionally with representatives of other disciplines, including Bioinformatics, Biology, and Mechanical/Electrical/Optical/Fluidic Engineering, to understand how the instrument software domain intersects with their work and to define and deliver solutions that best support their efforts
Drive changes to meet the standards of practice for our software engineering processes
Provide support to existing systems
Qualification
Required
A minimum of 7+ years of relevant experience in a high performing software engineering organization is required
A minimum of 5 years of experience delivering solutions to complex hardware control challenges on-time and with high quality
A bachelor's degree in an engineering or scientific field is required
Have a solid grasp of computer science fundamentals and an eagerness to tackle challenging, unique problems
Fluency in C/C++
Fluency in Python
Experience with microcontrollers running an RTOS
Familiarity with low-level communication protocols, e.g. TCP/UDP ethernet, RS 232/422/485 serial communications, USB-HID
Strong expertise in concurrent/multithreaded programming
Experience working with Linux hardware drivers
Have strong organization and communication skills with the ability to lead directly as well as through collaboration and influence
Have fun when building complex systems while working side-by-side with experts from a variety of engineering and scientific disciplines
Thoughtfully adapt testing methodology and tools to reproduce non-deterministic failures and quickly achieve highly reliable systems
Preferred
Previous work within the biotechnology industry is highly desired
Experience with automated provisioning and deployment systems
Experience creating and maintaining automated CI/CD systems and testing
Familiarity with high-level communication protocols, e.g. ReST-APIs, message queues, event streams
Experience with imaging systems, especially TDI cameras and hardware-controlled autofocus systems
Company
Nautilus Biotechnology
Nautilus Biotechnology is a life sciences company that develops a platform for analyzing and quantifying the human proteome.
51-200 employees
H1B Sponsorship
Nautilus Biotechnology has a track record of offering H1B sponsorships. Please note that this does not
guarantee sponsorship for this specific role. Below presents additional info for your
reference. (Data Powered by US Department of Labor)
Distribution of Different Job Fields Receiving Sponsorship
Represents job field similar to this job
Trends of Total Sponsorships
2025 (3)
2023 (2)
2022 (6)
2021 (1)
2020 (2)
Funding
Current Stage
Public CompanyTotal Funding
$304.8MKey Investors
Michael J. Fox FoundationPerceptive AdvisorsVulcan Capital
2026-01-28Grant· $1.6M
2021-06-10Post Ipo Equity· $200M
2021-06-09IPO
Leadership Team
Mary Godwin
Sr. Vice President, Operations, Nautilus Biotechnology
Martin Huber
VP of Biochemistry and Flow Cell Development
Recent News
Longevity.Technology
2026-01-17
Nautilus Biotechnology Inc.
2025-12-24
Company data provided by crunchbase