Centessa Pharmaceuticals · 1 month ago
Senior Scientist, DMPK
United States
Full-time
Remote
Mid, Senior Level
$160K/yr - $180K/yr
4+ years expCentessa Pharmaceuticals plc is a new kind of pharmaceutical company with a focus on data-driven decision making. They are seeking a Senior Scientist in Discovery DMPK to collaborate with pharmacologists and medicinal chemists in identifying lead candidates with optimal DMPK properties for development.
BiotechnologyLife SciencePharmaceuticalClinical Trials
Responsibilities
Design profiling strategies (including in vitro ADME assays) to evaluate compounds and series emerging from hit identification effort
Design PK/PD strategies to advance lead identification and optimization series
Protocol development and data analysis of PK and PK/PD studies for proof-of-concept studies
Review statements of work (SOWs) to ensure alignment with project objectives
Analyze and interpret in vitro and in vivo PK and PK/PD data, ensuring accuracy and consistency
Utilize AI tools in prediction of PK properties and guide the use of such technology in supporting SAR development in lead identification and optimization phases
Author and review compound checklists for drug candidate progression
Represent the DMPK function in project team meetings; present results and contribute to data-driven decision-making
Qualification
Required
Ph.D. in Pharmaceutical Sciences, Pharmacology or a related field
Minimum of 4 years of industry experience in a biotech or pharmaceutical setting
Proficiency with Phoenix WinNonlin and other software for PK and PK/PD modeling in small molecule drug discovery is essential
Previous work in the early discovery and lead optimization of CNS drug candidates is essential
Strong analytical and problem-solving skills
Demonstrated ability to work cross-functionally and communicate scientific findings clearly and effectively
Collaborative mindset and sense of urgency
Proactive and excellent communication skills
Benefits
Discretionary annual bonus
Participation in our equity program
401(k) plan
Company-sponsored medical, dental, vision, and life insurance
Generous paid time off
Health and wellness program
Company
Centessa Pharmaceuticals
Centessa Pharmaceuticals is a pharmaceutical company that focuses on drug development to address significant medical needs.
51-200 employees
H1B Sponsorship
Centessa Pharmaceuticals has a track record of offering H1B sponsorships. Please note that this does not
guarantee sponsorship for this specific role. Below presents additional info for your
reference. (Data Powered by US Department of Labor)
Distribution of Different Job Fields Receiving Sponsorship
50%
Represents job field similar to this job
Engineering and Development
Management and Executive
Trends of Total Sponsorships
*2025 (1)
2024 (1)
Funding
Current Stage
Public CompanyTotal Funding
$1.12BKey Investors
Oberland CapitalGeneral Atlantic,Janus Henderson Investors,Vida Ventures
2026-03-31Acquired
2025-11-11Post Ipo Equity· $250M
2024-09-11Post Ipo Equity· $225M
Leadership Team
John Crowley
Chief Financial Officer
Gregory Weinhoff
Chief Business Officer
Recent News
Foresite Capital
2026-07-03
2026-06-26
Company data provided by crunchbase