Centessa Pharmaceuticals · 3 months ago
Senior Director, Clinical Pharmacology
United States
Full-time
Remote
Director/Executive
$270K/yr - $295K/yr
8+ years expCentessa Pharmaceuticals plc is a new kind of pharmaceutical company with a focus on data-driven decision making. They are seeking an experienced Senior Director, Clinical Pharmacology to provide scientific and strategic leadership for clinical pharmacology across a diverse pipeline, particularly in neuroscience drug development.
BiotechnologyLife SciencePharmaceuticalClinical Trials
Responsibilities
Lead clinical pharmacology strategy for CNS and neuroscience programs from first‑in‑human through registrational and post‑marketing stages
Design, execute, and interpret clinical pharmacology studies, including FIH, multiple‑ascending dose, DDI, biopharmaceutics, and patient studies
Drive dose selection and optimization by integrating PK, PD, safety, efficacy, and CNS‑specific biomarkers
Lead model‑informed drug development, including population PK, PK/PD, and exposure–response analyses relevant to CNS targets and clinical safety
Assess and guide strategies for CNS exposure, brain penetration, target engagement, and translational biomarkers
Serve as the clinical pharmacology lead on program teams, clinical sub‑teams, and trial working groups
Author and oversee clinical pharmacology sections of regulatory documents (e.g., INDs, CTAs, IBs, NDAs)
Represent clinical pharmacology in interactions with FDA and other global health authorities, supporting dose justification and labeling discussions
Partner closely with DMPK, Translational Sciences, Clinical Development, Biomarkers, Biostatistics, CMC, and Regulatory Affairs
Oversee CROs and external vendors conducting clinical pharmacology and modeling activities
Ensure timely communication and clear interpretation of clinical pharmacology results to internal stakeholders
Contribute to portfolio strategy, program prioritization, risk mitigation, and long‑range clinical development planning for CNS assets
Serve as a subject‑matter expert on clinical pharmacology
Mentor and develop clinical pharmacology talent as the pipeline and organization grow
Ensure high‑quality, submission‑ready documentation aligned with global regulatory standards
Qualification
Required
PhD, PharmD, or MD in Clinical Pharmacology, Pharmacokinetics, Pharmaceutical Sciences, or a related discipline
8–12+ years of experience in clinical pharmacology within biopharma, with demonstrated impact in clinical drug development
Extensive experience developing and executing clinical pharmacology strategies for early‑ through late‑stage programs, including registrational support
Strong expertise in PK, PD, PK/PD integration, exposure–response analyses, and drug–drug interaction assessment
Demonstrated experience applying quantitative clinical pharmacology approaches (e.g., population PK, mechanistic PK/PD modeling) to inform CNS dose selection and optimization
Proficiency with clinical pharmacology tools and platforms such as NONMEM, R, Phoenix WinNonlin, SimCyp, or equivalent
Experience authoring and delivering clinical pharmacology components of regulatory submissions (e.g., INDs, CTAs, NDAs) and interacting with global health authorities
Strong understanding of translational PK, CNS exposure considerations, and biomarker integration in neuroscience drug development
Excellent communication, collaboration, and leadership skills with the ability to operate effectively in a fast‑paced, matrixed environment
Benefits
Discretionary annual bonus
Participation in our equity program
401(k) plan
Company-sponsored medical, dental, vision, and life insurance
Generous paid time off
Health and wellness program
Company
Centessa Pharmaceuticals
Centessa Pharmaceuticals is a pharmaceutical company that focuses on drug development to address significant medical needs.
51-200 employees
H1B Sponsorship
Centessa Pharmaceuticals has a track record of offering H1B sponsorships. Please note that this does not
guarantee sponsorship for this specific role. Below presents additional info for your
reference. (Data Powered by US Department of Labor)
Distribution of Different Job Fields Receiving Sponsorship
50%
Represents job field similar to this job
Engineering and Development
Management and Executive
Trends of Total Sponsorships
*2025 (1)
2024 (1)
Funding
Current Stage
Public CompanyTotal Funding
$1.12BKey Investors
Oberland CapitalGeneral Atlantic,Janus Henderson Investors,Vida Ventures
2026-03-31Acquired
2025-11-11Post Ipo Equity· $250M
2024-09-11Post Ipo Equity· $225M
Leadership Team
John Crowley
Chief Financial Officer
Gregory Weinhoff
Chief Business Officer
Recent News
Pharmaceutical Technology
2026-08-07
The Motley Fool
2026-08-06
Boston Globe
2026-08-06
Company data provided by crunchbase