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Director, Peptide Process Development jobs in United States
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Alnylam Pharmaceuticals · 2 weeks ago

Director, Peptide Process Development

positionUnited States
timeFull-time
remoteRemote
seniorityDirector/Executive
money$197K/yr - $267K/yr
date10+ years exp
Alnylam Pharmaceuticals is a leader in RNAi therapeutics, and they are seeking a Director of Peptide & Peptide-Oligonucleotide Conjugate Process Development. This role involves providing technical leadership for the development, scale-up, and external manufacture of peptide and POC active pharmaceutical ingredients, ensuring robust and regulatory-ready processes from development through supply.
BiotechnologyHealthcarePharmaceuticalHealth CareMedicalTherapeutics
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Comp. & BenefitsbadNo H1Bnote

Responsibilities

Lead process development, optimization, scale up, and characterization of peptides and contribute to the development of peptide oligonucleotide conjugate (POC) APIs with internal stakeholders
Serve as the technical lead for peptide and POC processes from development through external GMP manufacture
Evaluate, select, and enable CDMOs; lead process transfer and external manufacturing activities
Author and review technical and regulatory documentation supporting API manufacture and filings
Integrate CMC process activities within TOQ and extended program teams
Contribute to long‑term peptide and POC platform strategy and delivery

Qualification

Peptide API developmentPeptide process scale-upPeptide process characterizationPeptide-drug conjugate process developmentOligonucleotide conjugate process developmentProcess transferCDMO GMP manufacturingCMC documentationRegulatory filings

Required

PhD in a relevant scientific discipline with 10+ years of industry experience in peptide and/or conjugate process development
Demonstrated expertise in peptide API development, scale up, and process characterization
Experience in process development, optimization, scale-up, and process characterization of peptide-drug conjugates and/or oligonucleotide conjugates
Proven experience leading process transfer and external CDMO-based GMP manufacturing
Experience supporting CMC documentation and regulatory filings
Ability to function as a technical owner within cross-functional program teams

Benefits

Annual short-term incentive award (e.g., bonus or sales incentive)
Annual long-term incentive award (e.g., equity)
Medical, dental, and vision coverage
Life and disability insurance
A lifestyle reimbursement program
Flexible spending and health savings accounts
A 401(k)with a generous company match
Paid time off
Wellness days
Holidays
Two company-wide recharge breaks
Generous family resources and leave

Company

Alnylam Pharmaceuticals

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Alnylam Pharmaceuticals is a biopharmaceutical company focused on the discovery, development and commercialization.
dateFounded in 2002
location
Cambridge, Massachusetts, USA
people-size1001-5000 employees
web-link
http://www.alnylam.com

Funding

Current Stage
Public Company
Total Funding
$4.55B
Key Investors
Blackstone Life SciencesBlackstone CreditRegeneron
2025-09-09Post Ipo Debt· $661.25M
2022-09-12Post Ipo Debt· $900M
2022-03-04IPO

Leadership Team

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Yvonne Greenstreet
Chief Executive Officer
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Jeff Poulton
Chief Financial Officer
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Recent News

GlobeNewswire
ALNYLAM INVESTIGATION ALERT: Bragar Eagel & Squire, P.C. is Investigating Alnylam Pharmaceuticals, Inc. on Behalf of Alnylam Stockholders and Encourages Investors to Contact the Firm
2026-08-05
Morningstar.com
ALNY Investors Have Opportunity to Join Alnylam Pharmaceuticals, Inc. Fraud Investigation with SBS Law
2026-08-04
GlobeNewswire
Securities Fraud Investigation Into Alnylam Pharmaceuticals, Inc. (ALNY) Continues – Shareholders Who Lost Money Urged To Contact The Law Offices of Frank R. Cruz
2026-08-04
Company data provided by crunchbase