Shasqi · 1 month ago
Principal Scientist, ADME/PK
United States
Full-time
Remote
Lead/Staff
$150K/yr - $180K/yr
4+ years expShasqi is a biotech company advancing a new class of targeted cancer therapies, built on Nobel prize-winning technology called click chemistry. They are seeking an experienced Principal Scientist, ADME/PK to lead pharmacokinetics, biodistribution, and translational modeling efforts for their next-generation tumor targeting technology in a fast-paced startup environment.
BiotechnologyHealthcareEmergency MedicineHealth CareMedical
No H1B
Responsibilities
Define and execute ADME/PK strategies for pre-targeted therapeutics that consist of biologics and small molecules
Lead PK/PD and biodistribution strategy to support platform validation and pipeline programs
Partner cross-functionally with chemistry, protein engineering, bioanalytical, and pharmacology/toxicology teams to optimize delivery efficiency and exposure
Serve as the subject matter expert on PK for pre-targeting systems and click chemistry-enabled therapeutics
Design, analyze, and interpret PK, biodistribution, and mass balance studies across components of the technology to guide therapeutic design, validation, and development
Collaborate with bioanalytical assay development team to support assay development
Build and apply PK/PD and mechanistic models to predict human dosing and scheduling
Translate preclinical data into clinical hypotheses and first-in-human strategies
Work closely with CMC and analytical teams to ensure bioanalytical readiness
Partner with toxicology and regulatory teams to support IND-enabling studies
Present data and strategy to leadership, investors, and external collaborators
Qualification
Required
PhD in Pharmacokinetics, Pharmaceutical Sciences, Bioengineering, or related field
4+ years of industry experience in ADME/PK (biotech/pharma), including ADME/PK leadership on therapeutic programs
Deep expertise in PK of biologics and/or targeted delivery systems (e.g., ADCs, radioconjugates, bispecifics)
Strong experience designing and interpreting in vivo PK and biodistribution studies
Demonstrated experience with QSP and PK/PD modeling
Experience with modeling tools (e.g., Phoenix WinNonlin, NONMEM, Monolix, MATLAB, or similar)
Preferred
Experience with pre-targeting approaches, multi-component therapeutics, or bioorthogonal chemistry systems
Familiarity with click chemistry reactions (e.g., tetrazine–TCO) in biological systems
Background in oncology, targeted therapeutics, or drug delivery platforms
Experience with imaging-based biodistribution (e.g., PET/SPECT, fluorescence)
Knowledge of regulatory expectations for PK/ADME in IND filings
Strong publication record and presentation skills
Benefits
Competitive base salary as part of a broader total rewards package.
Equity: Included as port of total compensations.
Comprehensive benefits: medical, dental, vision, 401(k) match, short- and long-term disability.
Flexible PTO and a WFH stipend to support remote work.
Ongoing growth opportunities, professional development, and mentorship.
Company
Shasqi
Pioneering in-human click chemistry against cancer
11-50 employees
Funding
Current Stage
Growth StageTotal Funding
$65.45MKey Investors
National Cancer InstituteY CombinatorNational Science Foundation
2021-12-08Grant· $1.9M
2021-11-11Series B· $50M
2021-04-27Grant· $2M
Leadership Team
José M. Mejía Oneto
Founder and CEO
Lindsay Daum
Executive Assistant To Chief Executive Officer
Recent News
PR Newswire
2025-07-11
Company data provided by crunchbase