Apply on Employer Site

Alnylam Pharmaceuticals · 2 weeks ago

Senior Associate Scientist, LNP Formulations

United States

Full-time

Remote

Mid Level

$80K/yr - $120K/yr

2+ years exp

Alnylam Pharmaceuticals is a leader in RNAi therapeutics, seeking a highly motivated Senior Associate Scientist for their Formulation Sciences team. The role involves conducting LNP formulation optimization, supporting studies, and contributing to scientific experiments and project activities.

BiotechnologyHealthcarePharmaceuticalHealth CareMedicalTherapeutics

Comp. & Benefits

No H1B

Responsibilities

Conduct LNP formulation optimization and characterization

Support in vitro/in vivo studies by producing LNPs encapsulating siRNAs and/or mRNAs

Generate analytical data to understand physicochemical parameters of LNPs across various payloads and to support projects in research/development

Support novel method development of LNP characterization and LNP delivery

Support formulations and analysis within formulation sciences team

Design, plan and perform scientific experiments and contribute to project related scientific activities with some guidance from team members

Analyze, summarize experimental data, and present scientific findings in the cross-functional teams

Maintain electronic lab notebook, SOPs, appropriate documentation for scientific data and experimental protocols

Work closely with scientists in Medicinal Chemistry, RNAi biology, and early development teams

Qualification

Lipid Nanoparticle (LNP) formulationIn-line mixingTangential Flow Filtration (TFF)Dynamic Light Scattering (DLS)Nanoparticle Tracking Analysis (NTA)Zeta potential measurementUV/fluorescence spectroscopyHigh Performance Liquid Chromatography (HPLC)Ultra Performance Liquid Chromatography (UPLC)Ribogreen assayCapillary electrophoresisGel electrophoresisMRNA encapsulationSiRNA encapsulationQuality Control (QC) analysis

Required

BS/MS in Chemical Engineering, Material Science and Engineering, Chemistry, Biochemistry, Pharmaceutical Sciences, or related discipline with 2-4 years of industry experience with a focus on LNP formulation and delivery systems

Direct experience in LNP formulation (in-line mixing and TFF), characterization (DLS, NTA, zeta potential, UV/fluorescence spectroscopy, HPLC, UPLC, ribogreen assay, capillary electrophoresis, gel electrophoresis, etc.), mRNA and siRNA encapsulation, and QC analysis is a must

Ability to work on multiple projects simultaneously and deliver conclusive results

Ability to quickly adapt to new priorities with responsibility in a fast-paced, dynamic, innovative environment

Goal oriented, highly organized with significant attention to details while maintaining highest scientific and ethical standards

Strategic and forward thinking

Strong team player with excellent verbal and written communication skills