Alnylam Pharmaceuticals · 2 weeks ago
Senior Associate Scientist, Oncology
United States
Full-time
Remote
Mid, Senior Level
$80K/yr - $120K/yr
3+ years expAlnylam Pharmaceuticals is a leader in RNAi therapeutics, and they are seeking a highly motivated Senior Associate Scientist skilled in bioconjugation chemistry to join their Oncology Research group. The role involves planning and executing protein conjugation experiments, developing purification methods, and collaborating with interdisciplinary teams to support oncology drug discovery projects.
BiotechnologyHealthcarePharmaceuticalHealth CareMedicalTherapeutics
No H1B
U.S. Citizen Only
Responsibilities
Independently plan and carry out protein conjugation experiments with oligonucleotide or other payloads to support in vitro and in vivo experiments
Improve upon or develop purification methods for novel protein conjugates using FPLC, HPLC and TFF
Design, synthesize and purify oligonucleotides modified with biorthogonal handles (e.g. maleimide, Azide, MeTz) for protein conjugation chemistry
Develop automation and/or plate-based protocols for the high throughput generation of new protein conjugates
Effectively troubleshoot synthetic and process challenges and independently come up with solutions
Supports group by contributing to the maintenance of laboratory infrastructure and equipment
Keep detailed and complete records in an electronic lab notebook and regularly communicate results to the team to progress drug discovery efforts
Qualification
Required
BS/MS degree in Chemistry, Chemical Biology, or a related field with 3-5 years of hands-on industry experience in protein conjugation chemistry
Deep expertise in biorthogonal chemistry with prior experience applying this knowledge to protein conjugation is required
Proficiency in synthetic chemistry lab techniques and strong working knowledge of instrumentation such FPLC, analytical and prep HPLC (IEX, SEC, RP), LC-MS, TFF, UV-Vis spectrometry, etc
Strong organizational, communication, and critical thinking skills
Excellent communicator, execution-focused and team-oriented
Good record keeping abilities to adequately document protocols and experimental data
Preferred
Experience working with antibody-oligonucleotide conjugates is strongly preferred
Experience with automation and/or plate-based protocols to improve conjugate throughput is a plus
Passionate about scientific discovery and eager to learn new skills and contribute to the success of the organization
Experience with Benchling ELN is a plus
Benefits
Eligible for an annual short-term incentive award (e.g., bonus or sales incentive)
Eligible for an annual long-term incentive award (e.g., equity)
Medical, dental, and vision coverage
Life and disability insurance
A lifestyle reimbursement program
Flexible spending and health savings accounts
A 401(k)with a generous company match
Paid time off
Wellness days
Holidays
Two company-wide recharge breaks
Generous family resources and leave
Company
Alnylam Pharmaceuticals
Alnylam Pharmaceuticals is a biopharmaceutical company focused on the discovery, development and commercialization.
1001-5000 employees
Funding
Current Stage
Public CompanyTotal Funding
$4.55BKey Investors
Blackstone Life SciencesBlackstone CreditRegeneron
2025-09-09Post Ipo Debt· $661.25M
2022-09-12Post Ipo Debt· $900M
2022-03-04IPO
Leadership Team
Yvonne Greenstreet
Chief Executive Officer
Jeff Poulton
Chief Financial Officer
Recent News
BioWorld Financial Watch
2026-07-18
2026-07-10
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