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Scientist, Organic Synthesis jobs in United States
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Alnylam Pharmaceuticals · 3 weeks ago

Scientist, Organic Synthesis

Alnylam Pharmaceuticals is a leader in RNAi therapeutics, and they are seeking a Scientist, Organic Synthesis to develop and optimize specialty starting materials for oligonucleotide drug manufacturing. The successful candidate will collaborate with cross-functional teams and external partners to ensure effective process development and compliance with regulatory standards.
BiotechnologyHealthcarePharmaceuticalHealth CareMedicalTherapeutics
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Comp. & Benefits
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Responsibilities

Contribute to process development, optimization, and scale-up of speciality starting materials
Support the process and product characterization of small molecules and oligonucleotide APIs
Contribute to the management and optimization of in-house and contract manufacturing processes
Author and review technical protocols and development reports in support of manufacturing and process characterization activities for CTA filing
Author, edit, and review manufacturing documentation according to regulatory and procedural guidelines
Support RA activities with authoring starting materials related
Work closely with analytical development, manufacturing technical operations, QA, QC, supply chain, Regulatory Affairs and CMO/CRO on the process transfer and process optimization
Contribute to strategic technical discussions and presenting progress at internal and external scientific meetings

Qualification

Organic synthesisProcess research and developmentSmall molecule manufacturingPeptide manufacturingOligonucleotide manufacturingProcess developmentAnalytical methods for process characterizationProduct characterizationTechnical protocol authoringManufacturing documentationRegulatory Affairs support

Required

Ph.D. in chemistry, chemical engineering, or biochemical engineering or B.S./M.S. with 7+ years of relevant experience
Process research and development experience in organic synthesis
Demonstrated proficiency in the design and development of practical processes for manufacture of small molecules, peptides and oligonucleotides
Hands-on experience in process development and analytical methods for process and product characterization
Excellent interpersonnel, organizational and communication skills
Demonstrated strong operational execution and problem-solving skills
Desire to work in a fast-paced, deadline-driven work environment

Benefits

Annual short-term incentive award (e.g., bonus or sales incentive)
Annual long-term incentive award (e.g., equity)
Medical, dental, and vision coverage
Life and disability insurance
A lifestyle reimbursement program
Flexible spending and health savings accounts
401(k)with a generous company match
Paid time off, wellness days, holidays, and two company-wide recharge breaks
Generous family resources and leave

Company

Alnylam Pharmaceuticals

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Alnylam Pharmaceuticals is a biopharmaceutical company focused on the discovery, development and commercialization.

Funding

Current Stage
Public Company
Total Funding
$4.55B
Key Investors
Blackstone Life SciencesBlackstone CreditRegeneron
2025-09-09Post Ipo Debt· $661.25M
2022-09-12Post Ipo Debt· $900M
2022-03-04IPO

Leadership Team

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Yvonne Greenstreet
Chief Executive Officer
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Jeff Poulton
Chief Financial Officer
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Company data provided by crunchbase