GondolaBio · 3 weeks ago
Vice President, Development
United States
Full-time
Remote
Director/Executive
$310K/yr - $360K/yr
12+ years expGondolaBio is a clinical-stage biopharmaceutical company focused on developing breakthrough therapeutics for genetic diseases. The Vice President of Development will provide scientific strategy and operational leadership across development sciences functions, guiding genetic disease programs from candidate selection through early clinical development.
BiotechnologyManufacturingPharmaceutical
Responsibilities
Provide scientific strategy and operational leadership across the development sciences functions that take genetic disease programs from candidate selection through first-in-human and early clinical development, including:
Direct nonclinical PK/PD strategy spanning target engagement, pharmacodynamic response, and efficacy
Oversee in vitro and in vivo ADME and DMPK characterization to support candidate selection and IND-enabling packages
Lead biomarker identification and the nonclinical-to-clinical biomarker strategy and execution
Drive clinical biomarker qualifications to support proof of mechanism and proof of concept
Own first-in-human through Phase 2 early clinical sciences and development strategy
Direct clinical pharmacology, including Phase 1 healthy-volunteer and special-population studies
Provide leadership across data analytics, pharmacometrics, biostatistics, and data management and data sciences to inform dose selection and program decisions
Oversee nonclinical and translational study execution and vendor management
Manage clinical pharmacology study execution and associated vendor relationships
Direct bioanalytical assay development for PK, biomarkers, and immunogenicity
Oversee nonclinical and clinical bioanalytical operations
Partner closely with Clinical Development, Global Regulatory Affairs, CMC, and Research to deliver integrated development plans and regulatory submissions (pre-IND, IND, FIH, Phase 1/2)
Personally drive the technical work across these functions, staying close to the science and the data while leveraging CROs and external partners to deliver, consistent with a lean, hands-on early-stage culture
Represent development sciences to senior leadership, the board, and external advisors, and contribute to portfolio-level prioritization and resourcing decisions
Qualification
Required
PhD, PharmD, MD, or equivalent advanced degree in a relevant scientific discipline
Minimum 12+ years of biopharmaceutical drug development experience, including significant time in technical leadership roles
Substantial drug development experience spanning nonclinical through early clinical development, with a track record of advancing programs into and through first-in-human
Demonstrated leadership across two or more of the following: nonclinical pharmacology/DMPK, biomarkers, clinical pharmacology, quantitative sciences, bioanalytical sciences, or research operations
Experience operating in a lean, build-oriented, clinical-stage environment with significant reliance on CROs and external vendors
Thrives in a hands-on, detail-oriented capacity and is energized by driving the work forward directly
Strong record of cross-functional partnership with Clinical Development, Regulatory, and CMC
Preferred
Direct experience with oligonucleotide therapeutics (ASO, siRNA, GalNAc-conjugated) or other novel modalities
Genetic and rare disease development experience
Experience building development sciences infrastructure and teams from an early stage
Benefits
Patient Days, where we are fortunate to hear directly from individuals living with the conditions we are seeking to impact throughout the year and learn how we can improve our efforts.
A culture inspired by our values: put patients first, think independently, be radically transparent, every minute counts, and let the science speak.
An unyielding commitment to always putting patients first.
A decentralized model that enables our program teams to focus on advancing science and helping patients. Our affiliate structure is designed to eliminate bureaucracy and put decision-making power in the hands of those closest to the science.
A place where you own the vision – both for your program and your own career path.
A collaborative, fast-paced, data-driven environment where we inspire ourselves and each other to always perform at the top of our game.
Access to learning and development resources to help you get in the best professional shape of your life.
Robust and market-competitive compensation & benefits package (Base, Performance Bonus, Equity, health, welfare & retirement programs).
Flexible PTO.
Rapid career advancement for strong performers.
Potential ability to work on multiple GondolaBio Pharma programs across multiple therapeutic areas over time.
Commitment to Diversity, Equity & Inclusion.
Company
GondolaBio
GondolaBio researches, develops and manufactures pharmaceutical products. It is a sub-organization of BridgeBio.
11-50 employees
Funding
Current Stage
Early StageTotal Funding
$300M2024-08-16Series Unknown· $300M
Leadership Team
J
James Li
President
Recent News
Clinical Trials Arena
2026-06-24
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