Vaxcyte · 2 weeks ago
Executive Director, Digital Enablement
United States
Full-time
Remote
Director/Executive
$288K/yr - $335K/yr
15+ years expVaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from bacterial diseases. The Executive Director, Digital Enablement will lead the development of digital infrastructure and AI capabilities to enhance commercial operations and ensure successful product launches.
PharmaceuticalBiotechnologyHealthcareBiopharmaHealth Care
Responsibilities
Develop a phased commercial digital vision for the US adult launch covering pre-launch, launch, and growth phases, with defined milestones and measurable outcomes at each stage
Own and maintain a commercial product roadmap that treats each digital capability — CRM, marketing technology, field enablement, analytics, AI tools — as a discrete product with a use case, a user, a success metric, and a release schedule
Map the end-to-end commercial experience from the account manager and field rep perspective through to provider and executive touchpoints, identifying where digital creates genuine leverage and where added complexity should be avoided
Define and prioritize AI use cases for field force effectiveness, marketing operations, customer segmentation, content production, and performance analytics — sequenced by business impact and data readiness
Ensure that no technology decision precedes a defined commercial use case; architecture follows strategy and vendor selection follows requirements
Serve as the commercial voice in all digital and technology planning conversations, ensuring that field, marketing, Medical Affairs, Market Access, and commercial operations priorities drive decisions
Translate commercial strategy into language that IT, vendors, and data teams can build from; translate technical constraints and trade-offs into language that commercial leaders can act on
Partner with Marketing to build the martech stack, performance marketing capability, and content infrastructure, and to streamline MLR review so approved content reaches the field faster. Identify where AI raises the ceiling — content generated and adapted at scale, and review workflows that move faster without lowering the bar
Partner with Sales and Field Force Excellence to equip the field with CRM, call planning, territory management, and mobile tools that make reps more effective in front of customers. Identify where AI raises the ceiling — next-best-action guidance, pre-call intelligence, and automation that returns selling time to reps
Partner with Medical Affairs to build capabilities to enable and enhance Medical Affairs activities, including digital engagement, scientific exchange tools, congress engagement platforms, and KOL mapping
Partner with Market Access and Commercial Operations to stand up contract management, chargeback and revenue management, and Sunshine Act compliance workflows that hold up under launch volume. Identify where AI raises the ceiling — anomaly detection, scenario modelling, and monitoring that flags issues before they surface
Serve as the primary liaison to the IT Commercial Lead (ITCL), ensuring technology implementation aligns with commercial strategy
The goal of this role is to examine every commercial launch capability area — marketing, field, Medical Affairs, market access, operations, and analytics — for where AI changes how the work gets done. That means building an organization that asks 'How would we create better outcomes using AI?','Approach every commercial capability decision with an AI-first lens: before adding headcount, process, or traditional software, evaluate whether AI can deliver more with less friction and at greater speed
Define and lead the AI capability roadmap for the commercial and medical affairs organizations, identifying both where AI makes current work better, where it makes new things possible, and where its use should be questioned
Deploy AI-powered strategic tools for the commercial leadership team, including virtual advisory simulations, pressure-testing frameworks, and intelligence briefing workflows
Champion AI literacy and adoption across commercial functions, building fluency from the ground up so that field and marketing teams are active users of AI tools
Establish AI governance guardrails for commercial contexts in partnership with Legal and Compliance, defining what is permitted, under what conditions, and with what oversight
Lead commercial evaluation of CRM, marketing automation, data, and AI vendor options — distinguishing between what to build, buy, and rent based on launch timelines, data readiness, and long-term scalability
Maintain a composable, modular platform philosophy — every component should be replaceable without forcing a full stack rebuild
Ensure that vendor contracts entered by the ITCL have commercial sign-off on scope, functionality, and success criteria before execution
Define the commercial data strategy: what data the organization needs to compete at launch, when it must be procured, and how it will be activated and governed across CRM, marketing, and analytics platforms
Partner with the ITCL to create the data architecture necessary to track and report commercial progress, ensuring performance metrics are captured, visible, and actionable across launch functions
Partner with IT and Finance to ensure a commercial view within the master data management framework so that supply chain, quality, and commercial teams are working from a shared customer record
Drive adoption of performance analytics and reporting tools across the commercial team, ensuring insights are accessible to field and marketing users
Qualification
Required
BA/BS degree in a scientific discipline, business, marketing, or technology required
MBA or other advanced degree highly desired
Minimum of 15+ years of industry-related experience with 5+ years in commercial or commercial-facing roles within pharmaceutical, biotech, or vaccine organizations, including direct exposure to product launch
Demonstrated experience operating with a product management discipline: owned a product roadmap, managed a backlog, worked in iterative delivery cycles, and measured outcomes
Experience building or leading a commercial digital or commercial excellence function, with accountability for adoption and business results, not just technical delivery
Deep understanding of the commercial technology ecosystem, including: CRM (e.g., Salesforce, Veeva, etc.), Marketing automation platforms, Data and analytics platforms, HCP-facing digital channels
Deep understanding of frontier AI models and their applications in business
Proven ability to translate in both directions: commercial strategy into technical requirements, and technical constraints into business options
AI fluency: genuine working knowledge of generative AI, predictive analytics, next-best-action tools, and AI-assisted content workflows
Ability to travel 20% of the time for commercial and cross-functional team engagements
Preferred
Experience launching U.S. vaccines and/or specialty biologics (highly preferred)
Familiarity with revenue management infrastructure including chargebacks, rebates, and gross-to-net systems
Familiarity with Sunshine Act compliance, MLR review workflows, and promotional materials management
Benefits
Comprehensive benefits
Equity component
Relocation assistance
Company
Vaxcyte
Vaxcyte focuses on developing vaccines designed to prevent or treat some of the most common and deadly infectious diseases worldwide.
501-1000 employees
H1B Sponsorship
Vaxcyte has a track record of offering H1B sponsorships. Please note that this does not
guarantee sponsorship for this specific role. Below presents additional info for your
reference. (Data Powered by US Department of Labor)
Distribution of Different Job Fields Receiving Sponsorship
14%
Represents job field similar to this job
Management and Executive
Engineering and Development
Accounting and Finance
Trends of Total Sponsorships
*2026 (1)
2025 (14)
2024 (7)
2023 (5)
2022 (7)
2021 (2)
Funding
Current Stage
Public CompanyTotal Funding
$4.48BKey Investors
CARB-XJanus Henderson Investors,RA Capital ManagementTPG Growth
2026-01-29Post Ipo Equity· $632.5M
2024-09-04Post Ipo Equity· $1.5B
2024-01-30Post Ipo Equity· $862.5M
Leadership Team
Grant Pickering
Co-Founder, CEO, Director
Andrew Guggenhime
President & Chief Financial Officer
Recent News
2026-08-05
Yahoo Finance
2026-06-22
2026-05-26
Company data provided by crunchbase