myGwork - LGBTQ+ Business Community · 3 days ago

Director, In Vivo Pharmacology ADC Lead

Bothell, WA

Full-time

Onsite

Director

$162K/yr - $269K/yr

10+ years exp

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Responsibilities

Lead a team of up to 15 in vivo scientists including PhD level.

Manage appropriate resourcing and prioritization efforts of sub-teams within the ADC in vivo group to ensure optimal portfolio progression and scientific rigor.

Provide supervision and mentorship of individuals in team to enable delivery of in vivo strategy and data to enhance our ability to accurately identify targets and drug candidates with high potential for success in the clinic - includes generating data to support efficacy, PK/PD relationship, combination strategy, biomarker identification and analysis.

Develop strategy for Translational Pharmacology ADC team to more accurately model oncology indications of strategic priority using in vivo systems.

Contribute to overall strategy across the department to strengthen the ability to model disease and efficiently leverage expertise and resource and enable a “one team” culture.

Serve as the in vivo pharmacology lead for several drug discovery projects.

Mentor individuals to develop and characterize new in vivo mouse models to study biologic mechanisms and support exploration of novel cancer therapeutics.

Provide interpretation of model systems in the context of clinical translatability.

Drive innovation through internal and external capabilities and collaborations

Generate and be accountable for the necessary Animal Use Protocols that ensures team members comply with all regulatory requirements and internal policies.

Contribute to relevant in vivo sections of study reports and regulatory documents, e.g., IND filings.

Ensure that projects have all critical in vivo data to enable project stage dependent decisions. Publication of results in scientific peer-reviewed journals and presentations at internal, national, and international meetings.

Qualification

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Oncology drug discoveryADC fieldAnimal models vivoEx vivoFlow cytometryWestern blotELISAScientific softwareOffice softwareSupervisoryMentoringLeadershipCollaborativeCommunicationPresentationDrug DiscoveryPreclinical DevelopmentGEMMHumanized ModelsScientific AccomplishmentsProblem SolvingCreativity