Iambic Therapeutics · 2 days ago

Director/Sr. Director GPCR Drug Discovery Biologist

SD Metro Area

Full-time

Onsite

Senior Level, Director

12+ years exp

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Responsibilities

Help guide strategy around GPCR drug discovery efforts, mentor and inspire a team of in vitro pharmacology and lead generation scientists to achieve data-driven outcomes efficiently, leveraging both internal and external resources

Partner with senior leadership to communicate vision and innovation in drug discovery in alignment with company goals.

Lead GPCR in vivo and in vitro pharmacology efforts

Lead and manage internal GPCR assay development (biochemistry and cell biology)

Drive GPCR drug discovery programs

Lead pharmacology efforts to support the advancement of GPCR drug discovery projects from hit ID through development candidate selection

Independently manage CRO scientists in the design, development, and implementation of in vitro/in vivo assays for the advancement of GPCR projects

Guide KOL interaction and research strategy for exploratory and early stage GPCR drug discovery efforts

Lead biology function within a multi-disciplinary teams/project which includes setting priorities, effectively communicating with, coordinating efforts and motivating team members.

Qualification

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Pharmaceutical industry experienceBiotechnology industry experienceCellular pharmacologyMolecular pharmacology vitro biologyGPCR drug discoveryMechanism of action characterizationPotency characterizationEfficacy characterizationStructured-guided drug discoveryEx-vivo models vivo models communicationOrganizational skillsFlexibilityQuick learning

Required

PhD in biochemistry, pharmacology or related field with a high level of expertise in GPCR pharmacology

At least 12 years of experience in pharmaceutical or biotechnology industries, 5-8 years of experience leading projects or teams

Demonstrated success applying cellular and molecular pharmacology in vitro biology tools to support and advance drug discovery programs with an emphasis of GPCR drug discovery

In depth knowledge of GPCR molecular pharmacology with specific expertise characterizing mechanism of action, potency, and efficacy of hits and leads

Exposure to structured-guided GPCR drug discovery desired

Experience with both ex-vivo and in vivo translational models desired

Excellent communication and organizational skills

Flexibility and ability to quickly learn new skills and knowledge on the job